化瘀软肝解毒方联合中频脉冲电治疗肝郁脾虚并湿热留恋型乙型肝炎肝硬化代偿期患者的疗效评估  

Evaluation of the therapeutic effect of Huayu Ruangan Jiedu formula combined with intermediate frequency pulse electrotherapy on patients with hepatitis B cirrhosis of liver depression and spleen deficiency combined with damp heat retention in the compensatory stage

作　　者：张琪铭 杨广栋[2] 韩雪 ZHANG Qi-ming;YANG Guang-dong;HAN Xue(Department of Gastroenterology and Hepatology,Cangzhou Hospital of Integrated TCMWM-Hebei,Qingxian Hebei,062650,China;不详)

机构地区：[1]河北省沧州中西医结合医院脾胃肝病科,河北青县062650 [2]河北省沧州中西医结合医院中医经典病房

出　　处：《中西医结合肝病杂志》2024年第10期879-883,共5页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：河北省中医药管理局科研计划项目(No.2022251)。

摘　　要：目的:评估化瘀软肝解毒方联合中频脉冲电治疗肝郁脾虚合并湿热留恋型乙型肝炎肝硬化代偿期患者的治疗效果。方法:选取2021年4月至2022年6月诊治的乙型肝炎肝硬化代偿期患者160例,用随机数字表法将其分为对照组和试验组,每组80例。两组患者均给予抗乙型肝炎病毒治疗,对照组患者给予中频脉冲电治疗,试验组患者在对照组治疗基础上给予化瘀软肝解毒方治疗。分析两组患者中医证候疗效,肝功能指标变化,上消化道出血、腹腔积液及肝细胞癌的发生率,生活质量调查简表(SF-36)评分的改善情况。结果:治疗后,试验组患者的总有效率高于对照组(P<0.05);治疗第26、52周以及治疗结束后第26周、52周,两组患者血清总胆红素(TBil)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)水平降低,白蛋白(Alb)、胆碱酯酶(CHE)水平升高,且试验组患者血清TBil、ALT、AST水平低于对照组,Alb、CHE水平高于对照组(P<0.05);试验组患者上消化道出血、腹腔积液及肝细胞癌的总发生率低于对照组(P<0.05);治疗后两组患者的SF-36评分均高于治疗前,且试验组高于对照组(P<0.05)。结论:化瘀软肝解毒方联合中频脉冲电治疗效果理想,安全性高,可明显保护肝功能,降低肝硬化重要并发症的发生率,提高患者生活质量。Objective:To evaluate the therapeutic effect of Huayu Ruangan Jiedu formula combined with intermediate frequency pulse electrotherapy on patients with hepatitis B cirrhosis of liver depression and spleen deficiency combined with damp heat retention in the compensatory stage.Methods:From April 2021 to June 2022,160 patients with compensatory cirrhosis of hepatitis B in our hospital were selected as the research objects.They were randomly grouped into the reference group and the test group by the number table method.Both groups were given anti-hepatitis B virus therapy.The reference group was treated with intermediate frequency pulse electrotherapy,while the test group was treated with Huayu Ruangan Jiedu formula combined with intermediate frequency pulse electrotherapy.The efficacy of traditional Chinese medicine syndromes,liver function indicators,the incidence of upper gastrointestinal bleeding,abdominal fluid accumulation,and primary liver cancer,and the quality of life questionnaire(SF-36) scores were compared between the two groups.Results:After treatment,the overall efficacy rate in the experimental group was higher than that in the control group(P<0.05).At weeks 26 and 52 of treatment,as well as 26 and 52 weeks after the conclusion of treatment,both groups showed reductions in serum total bilirubin(TBil),alanine aminotransferase(ALT),and aspartate aminotransferase(AST) levels,alongside increases in albumin(Alb) and cholinesterase(CHE) levels.However,the experimental group exhibited significantly lower serum TBil,ALT,and AST levels and higher Alb and CHE levels compared to the control group(P<0.05).Additionally,the overall incidence of upper gastrointestinal bleeding,ascites,and hepatocellular carcinoma in the experimental group was lower than that of the control group(P<0.05).Post-treatment,SF-36 scores in both groups were higher than before treatment,with the experimental group scoring higher than the control group(P<0.05).Conclusion:The combination of Huayu Ruangan Jiedu Formula and intermediate frequency

关 键 词：肝郁脾虚 湿热留恋型 乙型肝炎肝硬化 代偿期 化瘀软肝解毒方 中频脉冲电治疗 

分 类 号：R575.2[医药卫生—消化系统]