小胶质细胞替代治疗在神经系统疾病中的研究进展  

Advances in microglia replacement therapy in neurological disorders

作　　者：李涛[1] 孟金城 张振[1] 李丹阳[1] LI Tao;MENG Jincheng;ZHANG Zhen;LI Danyang(Department of Pathology,The First Affiliated Hospital of Harbin Medical University,Harbin 150007,China)

机构地区：[1]哈尔滨医科大学附属第一医院病理科,黑龙江哈尔滨150007

出　　处：《中国病理生理杂志》2024年第10期1975-1979,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81901191);哈尔滨医科大学优秀青年基金资助项目(No.2021Y13);2023哈尔滨医科大学校青年基金资助项目(No.0201-31041230008)。

摘　　要：小胶质细胞是中枢神经系统中主要的免疫细胞,小胶质细胞活化在神经系统损伤及神经退行性病变中起到重要的作用。近年来针对小胶质细胞靶向治疗的研究逐渐受到人们的重视。其中,小胶质细胞替代疗法即通过药物或基因靶向强制去除功能障碍的小胶质细胞并用完全分化的细胞重新替代,已经在多种神经系统疾病治疗中初见成效。本文对小胶质细胞替代治疗在阿尔茨海默病、中风等神经系统疾病中潜在的病理生理机制及有效的治疗策略进行了阐述,为深入研究神经系统疾病的病理生物学机制及治疗提供参考。Microglia are the primary immune cells in the central nervous system.The activation is of microglia crucial in neurological injury and neurodegenerative diseases.In recent years,research on microglia-targeted therapies has gained increasing attention.Microglia replacement therapy has shown promising results in treating various neurological diseases.This therapy involves the forced removal of dysfunctional microglia and their replacement with fully differentiated microglia through drug or gene targeting.This article discusses the potential pathophysiological mechanisms and effective therapeutic strategies of microglia replacement therapy in neurological diseases,including Alzheimer´s disease and stroke.Moreover,it serves as a reference for the in-depth study of neurobiological mechanisms and treatment of neurological diseases.

关 键 词：小胶质细胞 神经炎症 细胞替代疗法 

分 类 号：R741[医药卫生—神经病学与精神病学] R392.12[医药卫生—临床医学] R979.5