靶向颗粒酶B分子影像探针的研究进展  

Progress of Molecular Imaging Probes Targeting Granzyme B

作　　者：王立琴 柳江燕[1,2] Wang Liqin;Liu Jiangyan(Department of Nuclear Medicine,The Second Hospital of Lanzhou University,Lanzhou,730030,China;The Second Clinical Medical School,Lanzhou University,Lanzhou,730030,China)

机构地区：[1]兰州大学第二医院核医学科,兰州730030 [2]兰州大学第二临床医学院,兰州730030

出　　处：《华中科技大学学报（医学版）》2024年第5期713-716,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：甘肃省自然科学基金资助项目(No.22JR5RA989)。

摘　　要：颗粒酶B作为一种免疫细胞肿瘤杀伤活性相关的生物分子,可以为恶性肿瘤免疫治疗疗效评估提供重要信息。目前相关分子探针都是基于颗粒酶B的特异性识别序列设计,按照不同的成像原理,可将其分为化学发光探针、荧光探针、正电子发射断层扫描探针。三种探针均具有良好的颗粒酶B靶向能力和实时成像的特点。但是各类探针也存在体内不稳定、易受体内其他环境影响等不足,未来仍需要进一步探究改进。该文对靶向颗粒酶B分子探针的特点和应用进行总结,以期为后续研究提供理论参考。Granzyme B,as a biologically active molecule related to the cytotoxic activity of immune cells against tumors,can provide important information for the evaluation of immunotherapy efficacy in malignant tumors.Currently,related molecular probes are designed on the basis of the specific recognition sequence of granzyme B.According to different imaging principles,these probes can be divided into chemiluminescent probes,fluorescent probes,and positron emission tomography probes.All three types of probes have good targeting ability for granzyme B and real-time imaging characteristics.However,various probes also have drawbacks,such as instability in the body and susceptibility to other environmental influences.Further research is still needed to address these issues.This article summarizes the characteristics and applications of targeted granzyme B molecular probes,aiming to provide a theoretical reference for subsequent studies.

关 键 词：肿瘤 免疫疗法 颗粒酶B 化学发光探针 荧光探针 正电子发射断层扫描探针 

分 类 号：R730.51[医药卫生—肿瘤] O657.3[医药卫生—临床医学]