EBV感染与胃癌风险关联的流行病学研究进展  

Research progress on epidemiologic associations between Epstein-Barr virus infection and risk of gastric cancer

作　　者：王馨羚 金昱 潘凯枫[1] 李文庆[1] Xinling Wang;Yu Jin;Kaifeng Pan;Wenqing Li(Department of Cancer Epidemiology,Peking University Cancer Hospital&Institute,State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,Beijing Key Laboratory of Carcinogenesis and Translational Research,Beijing 100142,China)

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所流行病学研究室,消化系肿瘤整合防治全国重点实验室,恶性肿瘤转化研究北京市重点实验室,北京市100142

出　　处：《中国肿瘤临床》2024年第15期780-784,共5页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金项目(编号:82273704)。

摘　　要：Epstein-Barr病毒(Epstein-Barr virus,EBV)是首个被发现与人类肿瘤相关的病毒,其与胃癌的关联近年来受到广泛关注。2014年癌症基因组图谱根据分子特征首次将胃癌分为4种亚型,并将EBV感染者单独归为一类—EBV阳性胃癌,该亚型胃癌患者具有独特的分子和临床病理特征。EBV感染胃上皮细胞,诱导宿主基因突变及表观遗传异常,通常被认为可能是EBV致癌的重要基础,但个体EBV感染与胃癌发生风险之间的关系尚不明确。本文汇总既往探讨不同EBV感染指标与胃癌之间关联的流行病学证据,并对EBV在胃癌致癌过程中的可能作用及潜在作用机制进行综述,以期为进一步阐明EBV感染与胃癌发生发展的关系提供借鉴。Epstein-Barr virus(EBV)is the first virus discovered to be associated with human tumors,and its association with gastric cancer has received widespread attention in recent years.In 2014,The Cancer Genome Atlas initially classified gastric cancer into four subtypes based on molecular characteristics,with EBV positive individuals grouped into a distinct subtype known as EBV-positive gastric cancer,which has unique molecular and clinicopathological characteristics.While EBV infection in malignant gastric epithelial cells and the induction of host genetic mutations and epigenetic abnormalities were generally considered as important bases for EBV carcinogenesis,the mechanisms underlying the relationship between EBV infection and gastric cancer risk remain unclear.We here summarize the existing epidemiological data supporting associations between different indicators of EBV infection and gastric cancer and provide an overview of the potential roles and mechanisms of EBV in gastric cancer carcinogenesis,which is expected to offer significant guidance for future studies elucidating the relationship between EBV infection and gastric cancer development.

关 键 词：EPSTEIN-BARR病毒 胃癌 发病机制 

分 类 号：R735.2[医药卫生—肿瘤]