m6A修饰在肿瘤细胞自噬中的作用  

The role of m^(6)A modification in tumor autophagy

作　　者：白洁 苏夏艺 魏秀珍 董亚玲 朱志博(综述) 张百红(审校) Jie Bai;Xiayi Su;Xiuzhen Wei;Yaling Dong;Zhibo Zhu;Baihong Zhang(The First Clinical Medical College,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Department of Oncology,940th Hospital of Joint Logistics Support Force of People's Liberation Army,Lanzhou 730050,China;The Faculty of Medicine,Northwest Minzu University,Lanzhou 730030,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州市730000 [2]中国人民解放军联勤保障部队第九四〇医院肿瘤科 [3]西北民族大学医学部

出　　处：《中国肿瘤临床》2024年第15期795-800,共6页Chinese Journal of Clinical Oncology

基　　金：甘肃省自然科学基金项目(编号:22JR5RA007)。

摘　　要：自噬是一种细胞自我降解过程,在维持细胞和生物体代谢功能中起着至关重要的作用。自噬功能失调与包括肿瘤在内的多种疾病有关。m^(6)A修饰作为真核生物体内主要的RNA内部修饰,通过影响自噬相关基因(autophagy associated gene,ATG)的表达或干扰自噬相关信号通路在调节肿瘤细胞自噬过程中发挥重要作用,异常的m^(6)A修饰会导致自噬失调并影响肿瘤的进展。然而,其在肿瘤自噬调控中的具体作用仍待探索。因此,本文综述了m^(6)A修饰在肿瘤细胞自噬中的作用,并探讨了其与肿瘤进展及其耐药的关系,旨在为开发新的治疗策略提供理论基础。Autophagy is a cellular self-degradation process essential for maintaining metabolic functions in cells and organisms.Dysfunctional autophagy has been linked to various diseases,including cancer.The m^(6)A modification,a major RNA modification in eukaryotes,plays a crucial role in regulating autophagy in tumor cells by regulating the expression of autophagy-associated genes(ATGs)or interfering with autophagy-related signaling pathways.Aberrant m^(6)A modification can lead to dysregulated autophagy and impact tumor progression.However,the specific role of m^(6)A in regulating tumor autophagy remains to be explored.Therefore,in this review,we discuss the role of m^(6)A modification in tumor cell autophagy and examine its relationship with tumor progression and drug resistance,aiming to provide a theoretical foundation for developing new therapeutic strategies.

关 键 词：自噬 m^(6)A甲基转移酶 m^(6)A脱甲基转移酶 m^(6)A结合蛋白 肿瘤 耐药 

分 类 号：R730.2[医药卫生—肿瘤]