二极管激光器介导光动力疗法在牙周牙髓联合病变中的研究  

Study on the application of photodynamic therapy mediated by diode laser in combined periodontal-endodontic lesions

作　　者：吴兆玉 王雪 顾烨辰 顾雪凝 Wu Zhaoyu;Wang Xue;Gu Yechen;Gu Xuening(Department of Endodontics,Suzhou Stomatological Hospital,Suzhou 210000,China)

机构地区：[1]苏州口腔医院牙髓科,苏州210000

出　　处：《中国医学装备》2024年第10期96-100,共5页China Medical Equipment

基　　金：江苏省卫生健康科研基金(2022ZD0020)。

摘　　要：目的:探讨二极管激光器介导的光动力疗法(PDT)联合根管内消毒在牙周牙髓联合病变患者中的临床应用价值。方法:选取2021年11月至2023年12月苏州口腔医院收治的100例牙周牙髓联合病变患者,按照随机数表法将其分为观察组和对照组,每组50例。对照组给予根管内消毒治疗,观察组在对照组治疗基础上给予PDT治疗,比较两组患者的临床疗效、根管内细菌数量,龈沟液炎性因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及干扰素-γ(IFN-γ)表达水平,以及牙周袋深度(PD)、龈沟出血指数(SBI)及牙周附着丧失(AL)相关指标。结果:观察组患者治疗后显效28例(占56%),有效20例(占40%),无效2例(占4%),治疗总有效率为96.00%;对照组显效20例(占40%),有效21例(占42%),无效9例(占18%),治疗总有效率为82.00%。观察组治疗总有效率高于对照组,差异有统计学意义(χ^(2)=4.639,P<0.05)。与对照组相比,观察组患者的根管内细菌数量显著减少,IL-6、TNF-α显著降低,差异有统计学意义(t=6.524、5.268,4.394,P<0.05);两组患者的IFN-γ比较差异无统计学意义(P>0.05)。治疗后两组患者的PD、SBI及AL指标均显著降低,且观察组较对照组指标水平更低,差异有统计学意义(t=5.401、6.309、7.006,P<0.001)。结论:PDT联合根管内消毒在治疗牙周牙髓联合病变时可显著提高临床疗效,降低根管内细菌数量和龈沟液炎性因子水平,改善牙周健康指标。Objective:To investigate the clinical application value of photodynamic therapy(PDT)mediated by diode laser,which combined with disinfection in root canal in patients with combined periodontal-endodontic lesions.Methods:A total of 100 patients with combined periodontal-endodontic lesions who admitted to the Suzhou Stomatological Hospital from November 2021 to December 2023 were selected,and they were randomly divided into the observation group and control group,with 50 cases in each group.The control group underwent disinfection treatment in root canal,and the observation group underwent PDT treatment based on the treatment of control group.The clinical efficacy,the bacteria count in root canal,the expression levels of inflammatory factors of gingival crevicular fluid,which included interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),as well as periodontal related indexes such as periodontal pocket depth(PD),gingival sulcus bleeding index(SBI)and periodontal attachment loss(AL),were compared between the two groups.Results:After treatment,the effect of 28 cases(56%)was significant,and that of 20 cases(40%)was effective,and 2 cases(4%)were ineffective,and the total effective rate was 96.00%in the observation group.The effect of 20 cases(40%)was significant,and that of 21 cases(42%)was effective,and 9 cases(18%)were ineffective,and the total effective rate was 82.00%in the control group.The total effective rate of the observation group was significantly higher that of the control group,with a statistically significant difference(χ^(2)=4.639,P<0.05).Compared with the control group,the bacteria count in root canal of observation group significantly decreased,and the IL-6 and TNF-αof observation group significantly decreased,and the differences were significant(t=6.524,5.268,4.394,P<0.05).There was no significant difference in IFN-γlevels between the two groups(P>0.05).After treatment,the PD,SBI and AL indicators in both groups significantly reduced,and the above indicators of observation grou

关 键 词：二极管激光器 光动力疗法(PDT) 根管内消毒 牙周牙髓联合病变 

分 类 号：R781.3[医药卫生—口腔医学]