丁酸维护动物肠道健康作用的研究进展  

Research Progress on the Mechanism of Butyric Acid in Maintaining Animal Intestinal Health

作　　者：高枫 崔耀明 管军军[1] GAO Feng;CUI Yaoming;GUAN Junjun(College of Biological Engineering,Henan University of Technology,Zhengzhou,Henan 450001,China)

机构地区：[1]河南工业大学生物工程学院,河南郑州450001

出　　处：《家畜生态学报》2024年第10期1-8,共8页Journal of Domestic Animal Ecology

基　　金：国家自然基金青年项目(32202697);河南工业大学2023年度青年骨干教师培育计划。

摘　　要：丁酸及其衍生物作为一种重要的肠道营养物质在维护动物肠道形态、调节动物肠道微环境及肠道菌群平衡、调节免疫等方面发挥重要作用。近期研究表明丁酸及其衍生物维护动物肠道微环境主要通过促进肠道细胞增殖影响肠道发育,通过提高小肠上皮细胞相关蛋白表达维护肠道屏障,同时通过调控肠道内环境及刺激相关免疫蛋白表达维持内环境稳态等。在调控能量代谢方面,丁酸及其衍生物能够直接分解为动物供能,作为能量摄入调节剂可调节相关基因表达,线粒体合成修复及神经回路传导。丁酸及其衍生物作为信号分子作用于免疫途径,调控免疫因子的基因及蛋白表达,抑制癌细胞增殖,改善肠道的免疫。该文主要总结了丁酸在动物体内合成和代谢途径及其维护动物肠道健康作用的机制,以期为丁酸产品开发提供理论基础。As a major intestinal nutrient,butyric acid and its derivatives play an important role in maintaining animal intestinal morphology,regulating the environment of animal intestinal flora,and regulating immunity.Previous studies have shown that butyric acid and its derivatives maintain the intestinal microenvironment of animals mainly by promoting intestinal cell proliferation and affecting intestinal development,maintain the intestinal barrier by improving the expression of relevant proteins in small intestinal epithelial cells,and maintain the homeostasis of the internal environment by regulating the intestinal environment and stimulating the expression of relevant immune proteins.In terms of regulating energy metabolism,butyric acid and its derivatives directively break down to become energy supply,or serve as an energy intake regulator to affect energy metabolism by regulating related genes,mitochondrial synthetic repair and neural circuits.In addition,butyric acid and its derivatives act as signaling molecules in the immune pathway,regulate the gene and protein expression of immune factors,inhibit the proliferation of cancer cells,and improve intestinal immunity.This article mainly discusses the research progress of the mechanism of butyric acid in maintaining animal intestinal health,in order to provide theoretical reference for the development of butyrate products.

关 键 词：丁酸 肠道健康 微环境 能量代谢 免疫调节 

分 类 号：S811.5[农业科学—畜牧学] S816.7[农业科学—畜牧兽医]