The current role of dendritic cells in the progression and treatment of colorectal cancer  

作　　者：Yuanci Zhang Songtao Ji Ge Miao Shuya Du Haojia Wang Xiaohua Yang Ang Li Yuanyuan Lu Xin Wang Xiaodi Zhao 

机构地区：[1]State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,National Clinical Research Center for Digestive Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China [2]Department of Gastroenterology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,China [3]Department of Experimental Surgery,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China [4]Department of Gastroenterology,the 988th Hospital of PLA Joint Logistics Support Force,Zhengzhou 450042,China

出　　处：《Cancer Biology & Medicine》2024年第9期769-783,共15页癌症生物学与医学（英文版）

基　　金：This study was supported by grants from the National Natural Science Foundation of China(Grant Nos.82222058,82073197,82273142,and 82173256).

摘　　要：Colorectal cancer(CRC)is the third most common cancer and the second leading cause of cancer-related deaths worldwide.Dendritic cells(DCs)constitute a heterogeneous group of antigen-presenting cells that are important for initiating and regulating both innate and adaptive immune responses.As a crucial component of the immune system,DCs have a pivotal role in the pathogenesis and clinical treatment of CRC.DCs cross-present tumor-related antigens to activate T cells and trigger an antitumor immune response.However,the antitumor immune function of DCs is impaired and immune tolerance is promoted due to the presence of the tumor microenvironment.This review systematically elucidates the specific characteristics and functions of different DC subsets,as well as the role that DCs play in the immune response and tolerance within the CRC microenvironment.Moreover,how DCs contribute to the progression of CRC and potential therapies to enhance antitumor immunity on the basis of existing data are also discussed,which will provide new perspectives and approaches for immunotherapy in patients with CRC.

关 键 词：Colorectal cancer dendritic cells tumor progression treatment strategies 

分 类 号：R735.34[医药卫生—肿瘤]