厚脉络膜病变的研究进展  

Research progress of pachychoroid spectrum disorders

作　　者：周贤慧 彭佳欣 邓文倩 喻娟[1,2,3] Zhou Xianhui;Peng Jiaxin;DengWenqian;Yu Juan(Department of Ophthalmology,The First Hospital of Hunan University of Chinese Medicine,Changsha 410000,China;The First Clinical School of Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410000,China;Hunan Key Laboratory for Prevention&Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine,Changsha 410000,China)

机构地区：[1]湖南中医药大学第一附属医院眼科,长沙410000 [2]湖南中医药大学第一中医临床学院,长沙410000 [3]中医药防治眼耳鼻咽喉疾病湖南省重点实验室,长沙410000

出　　处：《中华眼底病杂志》2024年第10期803-807,共5页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金(面上项目)(81973910);湖南省中医药管理局科研项目(2021057);2021杰出创新青年项目(kq2107014);湖南省研究生创新项目(CX20210728、CX20220813)。

摘　　要：厚脉络膜谱系疾病(PSD)是具有病理性脉络膜增厚等共同特征和潜在病理机制的一组临床疾病。PSD病理机制十分复杂,静脉过载学说为其提供了有价值的研究方向。以光相干断层扫描血管成像为代表的多模式影像学检查技术不断更迭贡献了清晰立体的眼底图像,便于对PSD进行早期诊断和监测疾病进展。PSD的治疗方案尚无统一定论,目前治疗方法包括药物治疗、激光光凝治疗、光动力疗法等,但相关研究提供的有效性和安全性证据仍不充分,外科手术和中西医结合治疗可能为PSD治疗提供新前景。今后需要进一步制定合理的研究方案,扩大样本量,加强随访观察,为患者提供更为安全有效的治疗方案。The pachychoroid spectrum disorders(PSD)refers to a group of clinical disorders characterized by common features of pathological choroidal thickening and potential pathogenic mechanisms.The pathological mechanism of PSD is very complex,and the theory of venous overload provides valuable research directions.The multimodal imaging technology represented by optical coherence tomography angiography has continuously evolved to provide clear and three-dimensional images of the fundus,making it easier to diagnose and monitor PSD at an early stage.There is no unified consensus on how to develop a treatment plan for PSD,and current research has shown that feasible treatments include drug therapy,laser photocoagulation therapy,and photodynamic therapy.However,the evidence of effectiveness and safety provided by these studies is still not sufficient.Surgery and integrative Chinese and Western medicine may provide new prospects for the treatment of PSD.In the future,it is necessary to further develop reasonable research programs,expand the sample size,strengthen follow-up observation,and provide more safe and effective treatment programs for patients.

关 键 词：厚脉络膜谱系疾病 脉络膜增厚 影像学 综述 

分 类 号：R773.4[医药卫生—眼科]