循环肿瘤细胞在乳腺癌新辅助及术后辅助治疗中的应用  

Application of circulating tumor cells in neoadjuvant and postoperative adjuvant therapy for breast cancer

作　　者：王玲艳 高春晖 冯雪园 崔鑫淼 刘欢 赵文明[1] 张金库[2,3] Wang Lingyan;Gao Chunhui;Feng Xueyuan;Cui Xinmiao;Liu Huan;Zhao Wenming;Zhang Jinku(Department of Breast Surgery,Baoding First Central Hospital,Baoding Hebei Province 071000,China;Department of Pathology,Baoding First Central Hospital,Baoding Hebei Province 071000,China;Key Laboratory of Molecular Pathology and Early Diagnosis of Tumor in Hebei Province,Baoding Hebei Province 071000,China)

机构地区：[1]保定市第一中心医院乳腺外科,河北保定071000 [2]保定市第一中心医院病理科,河北保定071000 [3]河北省分子病理与肿瘤早期诊断重点实验室,河北保定071000

出　　处：《中华普外科手术学杂志（电子版）》2024年第6期630-633,共4页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

基　　金：河北省医学科学研究计划项目(20220282);保定市科技计划项目(2141ZF237)。

摘　　要：目的探讨循环上皮细胞采样针(CellCollector)体内循环肿瘤细胞(CTC)捕获系统在乳腺癌患者中疗效监测和临床意义。方法回顾性分析2018年1月至2022年12月110例乳腺癌患者的临床资料,根据CTC检测结果(阈值为1个)将乳腺癌患者分成CTC阴性组(n=34例)和CTC阳性组(n=76例)。采用SPSS 23.0软件分析数据。符合正态分布的计量数据采用(χ±s)表示,组间比较采用独立样本t检验;计数资料以[例(%)]表示,组间比较采用χ^(2)检验或Fisher确切概率法;相关性分析采用Spearman法。P<0.05为差异有统计学意义。结果乳腺癌不同临床特征中,基线阳性CTC检出率在不同分子分型(LuminalA、LuminalB、TNBC、HER-2阳性)、HR(阳性、阴性组)、Ki-67(高、中、低组)中,差异显著,P值分别为0.021、0.043、0.041,均具有统计学意义。结论CellCollector体内CTC捕获技术在乳腺癌患者中检出率较高,检出率与乳腺癌分子分型、HR分型、ki67表达水平相关,为CTC识别高复发风险人群预测预后提供了依据。Objective To investigate the efficacy monitoring and clinical significance of circulating tumor cell(CTC)capture system with CellCollector in breast cancer patients.Methods Clinical data of 110 patients with breast cancer from January 2018 to December 2022 were retrospectively analyzed,and the patients were divided into CTC-negative group(n=34 cases)and CTC-positive group(n=76 cases)according to the results of CTC detection(threshold was 1).SPSS 23.O software was used to analyze the data.Measurement data conforming to normal distribution were represented by(X±s),and independent sample t test was used for comparison between groups.The count data were presented as[cases(%)].X test or Fisher exact probability method were used for comparison between groups.Spearman method was used for correlation analysis.P<0.05 was considered statistically significant.Results In different clinical characteristics of breast cancer,the baseline positive CTC detection rate was significantly different in different molecular types(LuminalA,LuminalB,TNBC,HER-2 positive),HR(positive and negative groups),and Ki-67(high,middle and low groups),with P values of 0.021,0.043,0.041,respectively.The results were statistically significant.Conclusion The detection rate of CTC capture technology in CellCollector was high in breast cancer patients,and the detection rate was relate d to the molecular typing,HR typing and ki67 expression level of breast cancer,which provided a basis for CTC to identify the population with high recurrence risk and predict the prognosis.

关 键 词：乳腺肿瘤 循环肿瘤细胞 细胞采样针 分子分类 

分 类 号：R737.9[医药卫生—肿瘤]