血清MG7-Ag水平、组织Notch-3水平对胃癌的诊断价值  

Diagnostic values of serum MG7-Ag level and tissue Notch-3level in gastric cancer

作　　者：吴鸾 冯秀娟[1] 张梅芳[1] 拉茸央宗 孙静[2] WU Luan;FENG Xiujuan;ZHANG Meifang;LA RONG Yangzong;SUN Jing(Gastroenterology Department,Second Medical Center of General Hospital of People’s Liberation Army,Beijing 100036,China;Health Care Department,Second Medical Center of General Hospital of People’s Liberation Army,Beijing 100036,China)

机构地区：[1]解放军总医院第二医学中心消化内科,北京100036 [2]解放军总医院第二医学中心保健一科,北京100036

出　　处：《中国实验诊断学》2024年第10期1151-1155,共5页Chinese Journal of Laboratory Diagnosis

基　　金：北京市科技计划项目(KJ2022CX32)。

摘　　要：目的分析血清胃癌相关抗原7(MG7-Ag)水平、组织神经源位点缺口同源蛋白3(Notch-3)水平对胃癌的诊断价值。方法回顾性分析2023年1月至12月解放军总医院第二医学中心收治的23例胃癌患者(胃癌组)及50例胃部良性病变者(良性病变组)的临床资料,统计2组患者的基线资料及血清MG7-Ag水平、组织Notch-3水平,分析胃癌的影响因素及血清MG7-Ag水平、组织Notch-3水平对胃癌的诊断效能;并比较不同胃癌患者的血清MG7-Ag水平、组织Notch-3水平,分析血清MG7-Ag水平、组织Notch-3水平与胃癌病理参数(肿瘤直径、TNM分期、血管浸润程度、淋巴结转移)的关系。结果胃癌组患者的血清胃蛋白酶原Ⅰ(PG1)水平低于良性病变组,胃泌素、癌胚抗原(CEA)、MG7-Ag及组织Notch-3水平均高于良性病变组(P<0.05),多因素Logistic回归分析可得出:胃泌素(95%CI:1.033~1.112)、CEA(95%CI:1.882~5.076)、MG7-Ag(95%CI:1.649~4.443)、Notch-3(95%CI:1.639~4.219)为胃癌的危险因素,PG1(95%CI:0.880~0.984)为胃癌的保护因素(P<0.05)。受试者工作特征曲线(ROC)分析结果显示血清MG7-Ag水平、组织Notch-3水平及联合诊断胃癌的敏感度分别为73.90%、78.30%、91.30%,特异度分别为86.00%、82.00%、80.00%;且联合诊断的AUC值为0.958,显著高于单一指标(P<0.05)。直径>3 cm、Ⅲ~Ⅳ级、有血管浸润及淋巴结转移的胃癌患者血清MG7-Ag水平、组织Notch-3水平高于直径≤3 cm、Ⅰ~Ⅱ级、无血管浸润及淋巴结转移者(P<0.05)。Pearson相关分析结果显示血清MG7-Ag水平、组织Notch-3水平与患者的肿瘤直径、TNM分期、血管浸润程度、淋巴结转移呈正相关关系(P<0.05)。结论胃癌患者的血清MG7-Ag水平、组织Notch-3水平均升高,其水平与肿瘤直径、TNM分期、血管浸润程度、淋巴结转移呈正相关关系,且两者联合对胃癌具有较高的诊断价值。Objective To analyze the diagnostic value of serum levels of gastric cancer-associated antigen 7(MG7-Ag)and tissue levels of neurogenic locus notch homolog protein 3(Notch-3)in gastric cancer.Methods A retrospective analysis was conducted on the clinical data of 23patients with gastric cancer(gastric cancer group)and 50patients with benign gastric lesions(benign lesion group)treated at the Second Medical Center of PLA General Hospital between January and December 2023.The baseline data,serum MG7-Ag levels,and tissue Notch-3levels of the patients in two groups were recorded.The influencing factors of gastric cancer,as well as the diagnostic performance of serum MG7-Ag levels and tissue Notch-3levels for gastric cancer were analyzed.The serum MG7-Ag levels and tissue Notch-3levels of the patients with different gastric cancer characteristics were compared,and the relationship between these levels and pathological parameters of gastric cancer(tumor size,TNM stage,vascular invasion,lymph node metastasis)was assessed.Results The serum pepsinogen I(PG1)level of the patients in gastric cancer group was lower than that in benign lesion group,while the level of gastrin,carcinoembryonic antigen(CEA),MG7-Ag,and tissue Notch-3of the patients were higher than those in benign lesion group(P<0.05).The multivariate Logistic regression analysis results showed that gastrin(95%CI:1.033~1.112),CEA(95%CI:1.882~5.076),MG7-Ag(95%CI:1.649~4.443),and Notch-3(95%CI:1.639~4.219)were the risk factors for gastric cancer,while PG1(95%CI:0.880~0.984)was a protective factor(P<0.05).The receiver operating characteristic(ROC)curve analysis results revealed that the sensitivities of serum MG7-Ag level,tissue Notch-3level,and their combined diagnosis of gastric cancer were 73.90%,73.00%,and 91.30%,respectively,while the specificities were 86.00%,82.00%,and 80.00%,respectively.The area under the curve(AUC)for the combined diagnosis(0.958)was significantly higher than that for the individual indicators(P<0.05).The patients with gastric cancer who had

关 键 词：胃癌相关抗原7 神经源位点缺口同源蛋白3 癌胚抗原 胃肿瘤 诊断 

分 类 号：R735.2[医药卫生—肿瘤]