环境微生物耐药阻控研究进展  

Progress on Antibiotic Resistance Control of Environmental Microorganisms

作　　者：高梦娣 朱琳 汪美贞[1,2] 李娜 Gao Mengdi;Zhu Lin;Wang Meizhen;Li Na(School of Environmental Science and Engineering,Zhejiang Gongshang University,Hangzhou 310018,China;Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling,Hangzhou 310018,China;College of Environmental Science and Engineering,Ocean University of China,Qingdao 260000,China)

机构地区：[1]浙江工商大学环境科学与工程学院,杭州310018 [2]浙江省固体废物处理与资源化重点实验室,杭州310018 [3]中国海洋大学环境科学与工程学院,青岛260000

出　　处：《生态毒理学报》2024年第5期40-49,共10页Asian Journal of Ecotoxicology

基　　金：国家自然科学基金资助项目(22306164,U21A20292,22076167);浙江省自然科学基金资助项目(LQ23B070004);浙江工商大学“数字+”学科建设项目(SZJ2022B015)。

摘　　要：世界卫生组织将微生物耐药视为21世纪全球健康的主要挑战之一。根据One Health观念,微生物耐药可以跨越生态边界在环境、动物、人体中传播,给生态安全和人类健康带来威胁。耐药菌株的快速传播和演变使得传统抗生素治疗效果逐渐减弱。因此,需要研究环境中耐药现状,提出缓解环境微生物耐药的策略。在该综述中,我们重点介绍缓解微生物耐药的策略,具体包括化学阻控、生物阻控、CRISPR-Cas系统应用和群落调节等手段,并对这些策略的优缺点进行了评述。这些策略有望遏制全球耐药的恶化及蔓延。Antibiotic resistance has been identified by the World Health Organization as one of the major global health challenges of the 21st Century.From a One Health perspective,the spread of antimicrobial resistance across ecological boundaries poses significant threats to human health and ecosystems.The efficacy of traditional antibiotics has been diminished by the rapid dissemination and evolution of resistant strains.Therefore,it is imperative that the current status of environmental antibiotic resistance be assessed and strategies to mitigate it be developed.In this review,several strategies to address antimicrobial resistance are examined,including chemical resistance control,biological resistance control,CRISPR-Cas system application,and community regulation.The advantages and disadvantages of each approach are evaluated.It is expected that these strategies will effectively curb the deterioration and spread of global drug resistance.

关 键 词：抗生素抗性基因 微生物耐药 化学阻控 生物阻控 群落调节 

分 类 号：X171.5[环境科学与工程—环境科学]