PD-L1和CD8在HER2阳性乳腺癌患者中的表达及其与病理参数相关性分析  

Expression of PD-L1 and CD8 in HER2 positive breast cancer and its clinicopathological significance

作　　者：赵甜甜 段超[1] 赵序雯 满其荣[2] 王祥阁[1] ZHAO Tiantian;DUAN Chao;ZHAO Xuwen;MAN Qirong;WANG Xiangge(Pathology Department,Tengzhou Central People’s Hospital,Tengzhou 277500,Shandong,China;Oncology Department,Tengzhou Central People’s Hospital,Tengzhou 277500,Shandong,China)

机构地区：[1]山东省滕州市中心人民医院病理科,山东滕州277500 [2]山东省滕州市中心人民医院肿瘤科,山东滕州277500

出　　处：《中国现代医生》2024年第29期45-49,共5页China Modern Doctor

基　　金：山东省滕州市中心人民医院“扬帆”计划(202406)。

摘　　要：目的通过评估程序性死亡受体配体1(programmed cell death-ligand 1,PD-L1)和分化群8(cluster of differentiation 8,CD8)在肿瘤微环境中的表达情况及其与患者临床病理特征的相关性,明确PD-L1和CD8在判断人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)阳性乳腺癌患者预后方面的作用。方法选取2016年10月至2018年10月山东省滕州市中心人民医院收治的HER2阳性乳腺癌患者65例,所有患者均为女性。癌组织切片经免疫组织化学方法标记PD-L1和CD8;收集患者的临床病理资料,包括年龄、组织学分级、P53、KI-67、雌激素受体、孕激索受体、肿瘤淋巴结转移分类(tumor node metastasis classification,TNM)分期在内的7项与预后相关的临床病理参数。分别分析PD-L1和CD8的表达是否和上述临床病理参数相关。结果PD-L1阳性表达率为21.5%,PD-L1阳性表达与组织学分级和TNM分期相关,差异有统计学意义(χ^(2)=6.250,P=0.044;χ^(2)=13.730,P=0.001);CD8阳性表达率为21.5%,CD8表达与组织学分级和TNM分期相关,差异有统计学意义(χ^(2)=8.023,P=0.018;χ^(2)=6.117,P=0.047)。结论PD-L1和CD8表达与乳腺癌组织学分级和TNM分期相关,可能是HER2阳性乳腺癌患者重要的预后标志物。Objective To determine the role of programmed cell death-ligand 1(PD-L1)and cluster of differentiation 8(CD8)in judging the prognosis of human epidermal growth factor receptor 2(HER2)positive breast cancer patients,through evaluating the expression of PD-L1 and CD8 in the tumor microenvironment,and their correlation with clinicopathological data.Methods A total of 65 HER2 positive breast cancer patients were collected admitted to Tengzhou Central People’s Hospital in Shandong Province from October 2016 to October 2018,all of whom were women.Theparaffin slices of cancer tissue were labeled with PD-L1 and CD8 using immunohistochemical methods.Collect clinicopathological data of patients,including 7 prognostic parameters,such as age,histological grade,P53,KI-67,estrogen receptor,progesterone receptor and tumor node metastasis classification(TNM)staging.Statistical analysis was conducted to determine whether the expression of PD-L1 and CD8 were correlated with the above clinicopathological data.Results PD-L1 positive rate was 21.5%,the positive expression of PD-L1 was correlated with histological grading and TNM staging,and the difference in results was statistically significant(χ^(2)=6.250,P=0.044;χ^(2)=13.730,P=0.001);CD8 positive rate was 32.3%,the expression of CD8 cells was correlated with histological grading and TNM staging,and the difference in results was statistically significant(χ^(2)=8.023,P=0.018;χ^(2)=6.117,P=0.047).Conclusion PD-L1 and CD8 expression are correlated with breast cancer histological grade and TNM stage.PD-L1 and CD8 expression may be important prognostic markers for HER2 positive breast cancer patients.

关 键 词：程序性死亡受体配体1 分化群8 人表皮生长因子受体2 乳腺癌 预后 

分 类 号：R737.9[医药卫生—肿瘤] R730.7[医药卫生—临床医学]