碘125放射性粒子植入治疗结直肠癌肝转移的安全性与短期疗效研究  

Clinical safety and short-term efficacy of Iodine-125 radioactive particle implantation in the treatment of colorectal cancer liver metastasis

作　　者：张灵芝 刘磊[1] 赵立峰[1] ZHANG Ling-zhi;LIU Lei;ZHAO Li-feng(Department of Intervention,Daqing Longnan Hospital,Daqing 163453,China)

机构地区：[1]大庆龙南医院介入科,黑龙江大庆163453

出　　处：《中国处方药》2024年第10期99-102,共4页Journal of China Prescription Drug

基　　金：大庆市指导性科技计划项目(zdy-2021-12)。

摘　　要：目的分析碘125放射性粒子植入治疗结直肠癌肝转移的临床安全性与短期治疗效果。方法选取某院2021年1月~2023年4月收治的40例结直肠癌肝转移患者为研究对象,根据随机数字表法分为两组。对照组(20例)采用全身化疗(Folfox或Folfiri方案),研究组(20例)采用全身化疗联合微创介入手术植入碘125放射性粒子治疗。比较两组患者粒子植入过程中及植入后的安全性、短期的治疗效果(2个月)、影像学评价、术后生活质量指数、实验室指标。结果两组并发症发生情况比较,差异无统计学意义(P>0.05);研究组总有效率(65.00%)显著高于对照组(25.00%)(P<0.05);治疗前两组肿瘤体积比较,差异无统计学意义(P>0.05),治疗后研究组肿瘤体积小于对照组(P<0.05);治疗前两组胃肠道生活质量指数(GIQLI)比较,差异无统计学意义(P>0.05),治疗后1个月、2个月研究组GIQLI高于对照组(P<0.05);治疗前两组CA125、CA19-9、CEA比较,差异无统计学意义(P>0.05),治疗后研究组CA125、CA19-9、低于对照组(P<0.05)。结论碘125放射性粒子植入治疗结直肠癌肝转移的短期治疗效果较好,可改善患者生活质量,缩小肿瘤体积,降低肿瘤标志物水平,且具有与单独全身化疗相似的安全性。Objective To analyze the clinical safety and short-term efficacy of iodine-125 radioactive particle implantation in the treatment of colorectal cancer liver metastasis.Methods 40 patients with liver metastasis of colorectal cancer admitted to a hospital from January 2021 to April 2023 were selected as the study objects and divided into two groups according to random number table method.The control group(20 cases)received systemic chemotherapy(Folfox or Folfiri regimen),and the study group(20 cases)received systemic chemotherapy combined with minimally invasive interventional surgery to implant iodine-125 radioactive particles.The safety during and after particle implantation,short-term therapeutic effect(2 months),imaging evaluation and postoperative life quality index、laboratory indicators were compared between the two groups.Results There was no significant difference in the incidence of complications between the two groups(P>0.05);the total effective rate of the study group(65.00%)was significantly higher than that of the control group(25.00%)(P>0.05).There was no significant difference in tumor volume between the two groups before treatment(P>0.05),after treatment,the tumor volume of the study group was smaller than that of the control group(P<0.05).There was no significant difference in GIQLI between the two groups before treatment,one month and two months after treatment,GIQLI of the study group were higher than that in the control group(P<0.05).There was no significant difference in CA125,CA19-9,CEA between the two groups before treatment(P>0.05).After treatment,CA125,CA19-9 and CEA in the study group were lower than those in the control group(P<0.05).Conclusion Iodine-125 radioactive particle implantation in the treatment of liver metastasis of colorectal cancer has good short-term therapeutic effect,can improve patients'quality of life,reduce tumor volume,reduce tumor marker level,and has similar safety as systemic chemotherapy alone.

关 键 词：碘125放射性粒子植入治疗 结直肠癌肝转移 安全性 短期治疗效果 

分 类 号：R735.34[医药卫生—肿瘤]