GenBase: A Nucleotide Sequence Database  

作　　者：Congfan Bu Xinchang Zheng Xuetong Zhao Tianyi Xu Xue Bai Yaokai Jia Meili Chen Lili Hao Jingfa Xiao Zhang Zhang Wenming Zhao Bixia Tang Yiming Bao 

机构地区：[1]National Genomics Data Center,Beijing Institute of Genomics,Chinese Academy of Sciences and China National Center for Bioinformation,Beijing 100101,China [2]CAS Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences and China National Center for Bioinformation,Beijing 100101,China [3]Human Genome Sequencing Center,Baylor College of Medicine,Houston,TX 77030,USA [4]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Genomics, Proteomics & Bioinformatics》2024年第3期107-112,共6页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB38030200);the National Key R&D Program of China(Grant No.2021YFF0703701);the Professional Association of the Alliance of International Science Organizations(Grant No.ANSO-PA-2023-07);the International Partnership Program of the Chinese Academy of Sciences(Grant No.161GJHZ2022002MI);the Open Biodiversity and Health Big Data Initiative of International Union of Biological Sciences(IUBS).

摘　　要：The rapid advancement of sequencing technologies poses challenges in managing the large volume and exponential growth of sequence data efficiently and on time.To address this issue,we present GenBase(https://ngdc.cncb.ac.cn/genbase),an open-access data repository that follows the International Nucleotide Sequence Database Collaboration(INSDC)data standards and structures,for efficient nucleotide sequence archiving,searching,and sharing.As a core resource within the National Genomics Data Center(NGDC)of the China National Center for Bioinformation(CNCB;https://ngdc.cncb.ac.cn),GenBase offers bilingual submission pipeline and services,as well as local submission assistance in China.GenBase also provides a unique Excel format for metadata description and feature annotation of nucleotide sequences,along with a real-time data validation system to streamline sequence submissions.As of April 23,2024,GenBase received 68,251 nucleotide sequences and 689,574 annotated protein sequences across 414 species from 2319 submissions.Out of these,63,614(93%)nucleotide sequences and 620,640(90%)annotated protein sequences have been released and are publicly accessible through GenBase’s web search system,File Transfer Protocol(FTP),and Application Programming Interface(API).Additionally,in collaboration with INSDC,GenBase has constructed an effective data exchange mechanism with GenBank and started sharing released nucleotide sequences.Furthermore,GenBase integrates all sequences from GenBank with daily updates,demonstrating its commitment to actively contributing to global sequence data management and sharing.

关 键 词：Nucleotide sequence DATABASE GenBase GENBANK INSDC 

分 类 号：Q492[生物学—生理学]