AVM:A Manually Curated Database of Aerosol-transmitted Virus Mutations,Human Diseases,and Drugs  

作　　者：Lan Mei Yaopan Hou Jiajun Zhou Yetong Chang Yuwei Liu Di Wang Yunpeng Zhang Shangwei Ning Xia Li 

机构地区：[1]College of Bioinformatics Science and Technology,Harbin Medical University,Harbin 150081,China

出　　处：《Genomics, Proteomics & Bioinformatics》2024年第3期133-138,共6页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Grant Nos.62172131,32070673,and 32070672);the China Brain Project(Grant No.2021ZD0202403);the Heilongjiang Touyan Innovation Team Program;the Outstanding Youth Project of Natural Science Foundation of Heilongjiang Province(Grant Nos.YQ2021C026 and YQ2022C034),China.

摘　　要：Aerosol-transmitted viruses possess strong infectivity and can spread over long distances,earning the difficult-to-control title.They cause various human diseases and pose serious threats to human health.Mutations can increase the transmissibility and virulence of the strains,reducing the protection provided by vaccines and weakening the efficacy of antiviral drugs.In this study,we established a manually curated database(termed AVM)to store information on aerosol-transmitted viral mutations(VMs).The current version of the AVM contains 42,041 VMs(including 2613 immune escape mutations),45 clinical information datasets,and 407 drugs/antibodies/vaccines.Additionally,we recorded 88 human diseases associated with viruses and found that the same virus can target multiple organs in the body,leading to diverse diseases.Furthermore,the AVM database offers a straightforward user interface for browsing,retrieving,and downloading information.This database is a comprehensive resource that can provide timely and valuable information on the transmission,treatment,and diseases caused by aerosol-transmitted viruses(http://www.bio-bigdata.center/AVM).

关 键 词：AEROSOL Viral mutation Immune escape mutation Human disease DRUG 

分 类 号：Q811.4[生物学—生物工程]