2005—2022年东莞市丙型肝炎流行特征及趋势分析  

Analysis of epidemic characteristics and trend of hepatitis C,Dongguan City,2005-2022

作　　者：邓星妤 张泽武[2] 杨华可[2] 方晓君[2] 宋艾婧 詹嘉慧 孔丹莉 丁元林 DENG Xing-yu;ZHANG Ze-wu;YANG Hua-ke;FANG Xiao-jun;SONG Ai-jing;ZHAN Jia-hui;KONG Dan-li;DING Yuan-lin(School of Public Health,Guangdong Medical University,Dongguan,Guangdong 523808,China;不详)

机构地区：[1]广东医科大学公共卫生学院,广东东莞523808 [2]东莞市疾病预防控制中心

出　　处：《现代预防医学》2024年第20期3672-3676,3681,共6页Modern Preventive Medicine

基　　金：广东医科大学学科建设项目(4SG21276P);广东医科大学本科教学质量与教学改革项目(1JG21086、1JG22125);广东医科大学大学生创新创业训练计划(SZDY001、2DC22104G、gdmu2022214);广东省基础与应用基础区域联合基金项目(重点项目)(2020B1515120021);广东省基础与应用基础研究基金企业联合基金(2022A1515220196);广东省本科教学质量与改革项目(2022610);广东省“新医学”建设指导委员会教学改革项目(2023183);粤港澳大湾区在线开放课程联盟教育研究与改革项目(2023068)。

摘　　要：目的分析2005—2022年东莞市丙肝的流行病学特征,为今后丙肝的防治工作提供科学的理论指导。方法收集各年份丙肝报告病例及人口学资料,采用Excel 2016、SPSS 25.0软件进行资料整理与统计分析,采用Joinpoint Regression Program 4.9.1.0软件进行丙肝变化趋势分析。检验水准α=0.05。结果2005—2022年东莞市丙肝年均报告发病率为12.84/10万。2005—2011年间报告发病率呈上升趋势(APC=15.74%),2011—2022年间报告发病率呈下降趋势(APC=-5.41%)。年均报告发病率排在前3的镇街有莞城街道(34.78/10万)、石龙镇(25.33/10万)、谢岗镇(17.90/10万)。男性年均报告发病率(17.45/10万)高于女性(8.17/10万),男性发病率自2014年起呈下降趋势(APC=-7.01%),女性发病率自2011年起呈下降趋势(APC=-7.64%)。病例主要集中在20~49岁人群(15873例,75.07%),50~59岁组报告发病率呈上升趋势(AAPC=24.47%)。家务及待业人群报告病例数最多(6003例,28.39%),且构成比呈上升趋势(AAPC=6.59%)。结论东莞市丙肝报告发病率高于全国发病水平,自2011年以来发病率呈下降趋势。建议重点加强男性、20~59岁组以及家务及待业人群的丙肝防治工作,有效降低丙肝发病水平。Objective To analyze the epidemiological characteristics of hepatitis C in Dongguan City from 2005 to 2022,and to provide scientific theoretical guidance for the prevention and treatment of hepatitis C in the future.Methods The reported cases and demographic data in Dongguan City from 2005 to 2022 were collected and analyzed by Excel 2016,SPSS25.0 and Joinpoint Regression Program 4.9.1.0 software.The value is 0.05 as a standard test.Results From 2005 to 2022 the average annual incidence of hepatitis C in Dongguan city was 12.84/100000.The annual incidence showed an upward trend from 2005 to 2011(APC=15.74%)and a downward trend from 2011 to 2021(APC=-5.41%).The incidence of reported cases in Guancheng district(34.78/100000),Shilong Town(25.33/100000)and Xiegang Town(17.90/100000)were among the top three in all the towns and streets.The average annual incidence in males(17.45/100000)was higher than that in females(8.17/100000),moreover,the incidence in male has declined since 2014(APC=-7.01%),and the incidence in female has declined since 2011(APC=-7.64%).The ages of onset were mainly from 20 to 49 years old(15873 cases,75.07%),In the age group of 50 to 59 years,the annual incidence showed an upward trend(AAPC=24.47%).The most affected population group was housewives and unemployed individuals(6003 cases,28.39%)and the annual constituent ratios was on the rise(AAPC=6.59%).Conclusion The reported incidence level of hepatitis C in Dongguan is higher than that in China.And the annual reported incidence has declined since 2011.Improving the prevention and cure of hepatitis C among men,20 to 59 age group and housewives and unemployed individuals is suggested to reduce the incidence of hepatitis C effectively.

关 键 词：丙型肝炎 流行特征 趋势 Joinpoint 

分 类 号：R575.1[医药卫生—消化系统]