益生菌及其衍生物在防治口源性口腔异味中的作用研究进展  

Research progress on the role of probiotics and its derivatives in the prevention and treatment of intra-oral halitosis

作　　者：孙小涵 赵蕾[1] 周婕妤 SUN Xiao-han;ZHAO Lei;ZHOU Jie-yu(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Periodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室国家口腔医学中心国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科,四川成都610041

出　　处：《中国实用口腔科杂志》2024年第5期584-590,共7页Chinese Journal of Practical Stomatology

基　　金：成都市科技局技术创新研发项目(2021-YF05-01864-SN);国家自然科学基金青年项目(82301089)。

摘　　要：口腔异味,又称呼气异味或口臭,是指口腔内呼出令人不悦的气味。临床中80%~90%的口腔异味为口内来源,即口源性口腔异味。与正常人相比,口源性口腔异味患者的口腔微生物群落多样性增加,且厌氧菌比例升高,其与口腔微生态失衡密切相关。益生菌是指当施以足够剂量时,能够给宿主带来益处的活体微生物;益生元、合生元及后生元均为益生菌衍生物,具有重建宿主微生物群落、改善宿主微生态的作用。文章就近年来益生菌及其衍生物在预防和治疗口源性口腔异味中的作用研究进展做一综述。Oral malodor,also known as breath malodor or halitosis,is an unpleasant odor exhaled from oral cavity.In the clinic,80%-90% of it is intra-oral halitosis.Compared with normal individuals,the patients with intra-oral halitosis have an increased diversity of oral microbiota,and an increased proportion of anaerobic bacteria,which is closely related to the imbalance of oral microbiota.Probiotics is defined as living microorganisms which,when administered in adequate amounts,confer a health benefit on the host.Prebiotics,synbiotics and postbiotics are derivatives of probiotics,which can rebuild the microorganisms community and improve the micro-ecology.In this paper,the research progress on the role of probiotics and their derivatives in the prevention and treatment of intra-oral halitosis is summarized.

关 键 词：口源性口腔异味 微生物 益生菌 

分 类 号：R78[医药卫生—口腔医学]