乳腺癌患者化疗过程中脑类淋巴功能动态变化研究  

A Study on the Dynamic Changes in Brain Glymphatic Function During Preoperative Chemotherapy in Breast Cancer Patients

作　　者：亓立强 吴越 王寒露 王艾博 安婧楠 王伟 QI Liqiang;WU Yue;WANG Hanlu(Department of Radiology,Beijing Rehabilitation Hospital Affiliated to Capital Medical University,Beijing 100144,P.R.China)

机构地区：[1]首都医科大学附属北京康复医院康复放射科,北京100144 [2]天津市肿瘤医院放射科,300060 [3]大连医科大学麻醉学系,116000

出　　处：《临床放射学杂志》2024年第11期1877-1881,共5页Journal of Clinical Radiology

摘　　要：目的探讨乳腺癌患者化疗过程中脑类淋巴功能的动态变化及其与认知功能的相关性。方法纳入80例女性乳腺癌患者。使用简易智力状态检查量表(MMSE)、蒙特利尔认知评估(MOCA)、数字符号连线检验(DSST)和癌症治疗功能评估(FACT)评分工具对认知功能进行评估,采用扩散张量成像血管周围间隙测量技术(DTI-ALPS)测量脑类淋巴功能。结果化疗后乳腺癌患者的各认知评分均明显下降。脑类淋巴功能参数ALPS指数在化疗后略增高,且与认知评分存在相关性。结论乳腺癌患者在化疗后脑类淋巴功能的动态变化,以及类淋巴功能与认知功能之间的密切关系,有助于深入理解化疗相关认知损伤(CRCI)状态下的脑类淋巴功能的变化规律,并为CRCI的发生机制提供新的研究视角。Objective To investigate the dynamic changes of brain lymphatic function during chemotherapy in patients with breast cancer and its correlation with cognitive function.Methods Eighty female patients with breast cancer were included in this study.Cognitive function was assessed using the MMSE,MOCA,DSST,and FACT scoring tools,and brain lymphatic function was measured using DTI-ALPS.Results After chemotherapy,the cognitive scores of breast cancer patients all showed a significant decline.The ALPS index,a parameter of brain lymphatic function,slightly increased after chemotherapy and was correlated with cognitive scores.Conclusion This study reveals the dynamic changes of brain lymphatic function in breast cancer patients after chemotherapy and the close relationship between lymphatic function and cognitive function.These findings contribute to a deeper understanding of the changing patterns of brain lymphatic function under CRCI conditions and provide new research perspectives for elucidating the mechanisms of CRCI.

关 键 词：乳腺癌 化疗相关认知损伤 扩散张量成像 脑类淋巴功能 

分 类 号：R737.9[医药卫生—肿瘤]