上皮剪切调控蛋白1在肿瘤中的研究进展  

Advances in the study of ESRP1 in tumors

作　　者：杨睿睿(综述) 李艳丽 何良 凌博 叶广彬(审校) Yang Ruirui;Li Yanli;He Liang;Ling Bo;Ye Guangbin(Institute of Life Sciences,Youjiang Medical University for Nationalities,Baise 533000;College of Basic Medical Sciences,Youjiang Medical University for Nationalities,Baise 533000;College of Medical Imaging,Youjiang Medical University for Nationalities,Baise 533000)

机构地区：[1]右江民族医学院生命科学研究院,百色533000 [2]右江民族医学院基础医学院,百色533000 [3]右江民族医学院医学影像学院,百色533000

出　　处：《安徽医科大学学报》2024年第9期1681-1687,共7页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金项目(编号:82060540);广西高校中青年教师科研基础能力提升项目(编号:2022KY0541);右江民族医学院2020年度校级科研课题(编号:yy2020ky028);广西壮族自治区区级大学生创新创业训练计划项目(编号:202210599019)。

摘　　要：上皮剪切调控蛋白1(ESRP1)是一种上皮细胞特异性剪接因子,参与多个基因的选择性剪接和翻译。在头颈部鳞状细胞癌、结直肠癌、前列腺癌等多种癌症中ESRP1通过介导靶基因、调节环状RNA的环化和生物生成等方式调控信号通路,影响细胞增殖和肿瘤生长。通过综合分析ESRP1与相关癌症之间的联系,为以ESRP1为关键因素的肿瘤细胞的治疗提供新思路。Epithelial splicing regulatory protein 1(ESRP1)is an epithelial cell-specific splicing factor that involved in selective splicing and translation of multiple genes.ESRP1 regulates signaling pathways that affect cell proliferation and tumor growth via mediating target genes and regulating cyclic RNA cyclization and biogenesis in a variety of cancers,including head and neck squamous cell carcinoma,carcinoma of colon,and prostate cancer.Through integrating and analyzing the link between ESRP1 and related cancers,provide new ideas for the treatment of tumor cells in which ESRP1 as a key factor.

关 键 词：上皮剪接调控蛋白1 上皮-间充质转化 选择性剪接 结直肠癌 乳腺癌 肺癌 

分 类 号：R730.2[医药卫生—肿瘤]