一锅多组分反应选择性合成二芳基甲胺和三芳基甲烷——推荐一个有机化学综合实验  

Selective Synthesis of Diarylmethyl Anilines and Triarylmethanes via Multicomponent Reactions:Introduce a Comprehensive Experiment of Organic Chemistry

作　　者：王一诺 王思然 赵奕龙 徐大振[1] Yinuo Wang;Siran Wang;Yilong Zhao;Dazhen Xu(National Engineering Research Center of Pesticide(Tianjin),State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China)

机构地区：[1]南开大学化学学院,农药国家工程研究中心,天津300071

出　　处：《大学化学》2024年第8期324-330,共7页University Chemistry

基　　金：国家级大学生创新创业训练计划(202310055078)。

摘　　要：本文介绍了一个有机化学综合实验,实验以水杨醛、苯硼酸和芳胺为反应底物,通过芳胺上取代基控制亲核性选择性地制备二芳基甲胺和三芳基甲烷,并利用核磁共振氢谱(^(1)H NMR)和碳谱(^(13)C NMR)对产物结构进行表征。本实验与理论知识相结合,启发学生进行机理方面的思考,帮助他们开拓知识视野,更好地树立“绿色化学”理念和环保意识。This article presents a comprehensive organic chemistry experiment in which salicylaldehyde,phenylboronic acid,and aromatic amines are employed as the substrates.The selective synthesis of diarylmethyl aniline and triarylmethane could be achieved through the control of substituents.The structure of the product is characterized by ^(1)H NMR and ^(13)C NMR.This experiment combines theoretical knowledge to inspire students to think about mechanisms,helps them broaden their knowledge horizons,and establishes the concept of"green chemistry"and environmental awareness.

关 键 词：多组分反应 苯胺 苯硼酸 绿色化学 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]