泛连接蛋白调控口颌面疼痛作用及机制的研究进展  

Research progress on the role and mechanism of pannexins in regulating oral and orofacial pain

作　　者：冯玉衡 刘飞 张艳艳[1] 沈颉飞[1] Feng Yuheng;Liu Fei;Zhang Yanyan;Shen Jiefei(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for OralDiseases&Dept.of Prosthodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院修复科,成都610041

出　　处：《国际口腔医学杂志》2024年第6期756-762,共7页International Journal of Stomatology

基　　金：国家自然科学基金(81870800,82071149,82271014)。

摘　　要：口颌面疼痛的病理机制复杂,临床上目前仍缺乏持久有效的治疗手段,给患者生活带来沉重负担。近年来,研究表明外周和中枢神经系统中的泛连接蛋白(PANX)在调控口颌面部疼痛的发生和发展中发挥着重要作用。本文重点阐述PANX的结构和功能,以及其在疼痛中的作用和机制,包括口颌面部的神经病理性疼痛、炎性疼痛和其他疼痛。通过深入了解PANX在口颌面部疼痛中的作用和功能,以期为口颌面部疼痛的诊断与治疗提供理论基础和治疗策略。The pathological mechanism of orofacial pain is complex,and long-lasting effective clinical treatment methods are lacking,causing a heavy burden on patients’lives.Pannexins(PANX),which are broadly expressed in the peripheral and central nervous systems,play a crucial role in regulating the development of orofacial pain.This review focus-es on the structure and function of PANX as well as its role and mechanism in pain,including neuropathic pain,inflamma-tory pain,and other orofacial pain.We aim to provide a theoretical basis and treatment strategies for the diagnosis and treatment of orofacial pain by gaining a deep understanding of the role and function of PANX.

关 键 词：泛连接蛋白 口颌面神经病理性疼痛 信号通路 三叉神经节 

分 类 号：R78[医药卫生—口腔医学]