金属基纳米粒子在控制根管感染中的应用  

Application of metal-based nanoparticles in controlling root canal infections

作　　者：董尚兰 冷沙 郑庆华[1] 张岚[1] 黄定明[1] Dong Shanglan;Leng Sha;Zheng Qinghua;Zhang Lan;Huang Dingming(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for OralDiseases&Dept.of Cariology and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu610041,China)

机构地区：[1]口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院牙体牙髓病科,成都610041

出　　处：《国际口腔医学杂志》2024年第6期785-792,共8页International Journal of Stomatology

基　　金：四川省自然科学基金(面上项目)(2022NSFSC0380)。

摘　　要：金属基纳米粒子具有良好的理化特性、生物相容性,以及特殊的光学和磁性能,广泛应用于口腔医学领域。金属基纳米材料可通过多种机制产生抗菌性能,包括氧化应激反应,直接破坏细菌细胞壁及细胞膜,以及释放金属离子等。根管治疗的目标是彻底消除根管系统内的感染,金属基纳米粒子可作为根管冲洗液、诊间药物和根管充填材料在根管治疗中发挥抗菌作用。目前在牙髓病学中有关银纳米粒子的研究比较充分。与传统的根管治疗材料相比,金属基纳米粒子具有更优良的抗菌表现。本综述为利用金属纳米粒子开发新的控制根管感染措施提供了思路和参考。Metal-based nanoparticles are extensively used in dentistry because of their good physicochemical proper-ties,biocompatibility,and special optical and magnetic properties.Metal-based nanomaterials can exhibit antimicrobial properties through various mechanisms such as oxidative stress induction,direct destruction of bacterial cell walls and cell membranes,and release of metal ions.The goal of root canal treatment is to completely eliminate infection within the root canal system.Metal-based nanomaterials can be used as irrigants,intracanal medications,and filling materials.Silver nanoparticles are currently well studied in endodontics.Metal-based nanoparticles have superior antimicrobial perfor-mance to conventional endodontic materials.This review provides ideas and references for the development of new mea-sures to control root canal infections by using metal nanoparticles.

关 键 词：金属基纳米粒子 根管感染 根管治疗 

分 类 号：R781.05[医药卫生—口腔医学]