Friedel-Crafts烷基化反应研究进展  

Research Advances in Friedel-Crafts Alkylation Reaction

作　　者：程诗砚 阮永红[1] 龚磊[1] 林玉妹 Shiyan Cheng;Yonghong Ruan;Lei Gong;Yumei Lin(College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,Fujian Province,China)

机构地区：[1]厦门大学化学化工学院,福建厦门361005

出　　处：《大学化学》2024年第10期408-415,共8页University Chemistry

基　　金：国家自然科学基金面上项目(22371237,22071209,22071206)。

摘　　要：Friedel-Crafts烷基化反应是一类重要的有机人名反应,常用于构建碳-碳键,在有机合成及药物化学等领域具有广泛的应用前景。本文介绍了Friedel-Crafts烷基化反应的基本原理,以及近年来利用金属催化、有机小分子催化、可见光催化、酶催化和电化学催化等策略所取得的新发展。将本科教学知识与前沿研究有机结合,有利于提高学生的学习兴趣,培养学生思维拓展能力。The Friedel-Crafts alkylation reaction represents a pivotal organic transformation for the formation of carbon-carbon bonds,holding extensive applications within the realms of both organic synthesis and pharmaceutical chemistry.This article presents a comprehensive review of the mechanism underlying the Friedel-Crafts alkylation reaction,alongside recent advancements in various catalytic approaches,such as metal catalysis,organocatalysis,visible light photocatalysis,enzymatic and electrochemical catalysis.By merging cutting-edge scientific developments with undergraduate teaching content,this review endeavors to inspire students’learning interests while fostering their capacity for innovative thinking.

关 键 词：Friedel-Crafts烷基化 有机合成 催化 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]