健脾法调整肝癌宿主肠道菌群增强免疫检查点抑制剂疗效的机制研究  

Mechanism Study on Adjusting Intestinal Flora of Hepatocellular Carcinoma Hosts with Spleen Strengthening Method to Enhance Efficacy of Immune Checkpoint Inhibitors

作　　者：田春红 王雄文[1] TIAN Chunhong;WANG Xiongwen(Guangzhou University of Chinese Medicine,Guangzhou Guangdong China 510405)

机构地区：[1]广州中医药大学,广东广州510405

出　　处：《中医学报》2024年第11期2278-2281,共4页Acta Chinese Medicine

基　　金：国家自然科学基金面上项目(82274605);广东省重点领域研发计划项目(2020B1111100011)。

摘　　要：肠道菌群的变化可以预测或影响免疫检查点抑制剂的疗效。脾虚与肝癌的发生发展、转归有关。在微观层面,“脾虚”的实质为肠道微生态的改变。健脾法可调整肝癌患者肠道菌群发挥抗肿瘤作用。因此,在使用免疫检查点抑制剂的基础上,中医健脾法可通过调整肝癌患者肠道菌群提高免疫治疗的疗效。基于调整宿主肠道菌群探讨健脾法联合免疫检查点抑制剂的增效机制可丰富“肝病实脾”的科学内涵,也为中西医结合防治恶性肿瘤提供契合点和证据。Changes in intestinal flora can predict or influence the efficacy of immune checkpoint inhibitors.Spleen deficiency is related to the development and regression of hepatocellular carcinoma.At the microscopic level,the essence of"Spleen deficiency"is the change of intestinal microecology.Strengthening the spleen can adjust the intestinal flora of hepatocellular carcinoma patients to exert anti-tumor effects.Therefore,based on the use of immune checkpoint inhibitors,Chinese medicine spleen strengthening method can improve the efficacy of immunotherapy by adjusting the intestinal flora of hepatocellular carcinoma patients.Exploring the efficacy of the spleenic method in combination with immune checkpoint inhibitors based on the adjustment of the host′s intestinal flora can enrich the scientific connotation of"strengthening Spleen in treatment of Liver disease",and provide a point of convergence and evidence for the combination of integrative medicine in prevention and treatment of malignant tumors.

关 键 词：健脾法 肠道菌群 免疫检查点抑制剂 肝癌 脾虚 肝病实脾 

分 类 号：R273.57[医药卫生—中西医结合]