乳牙龋儿童与健康儿童唾液总SIgA和菌斑主要致龋菌表达的差异性及临床意义  

Differences and clinical significance in total salivary SIgA and expression of major cariogenic bacteria in dental plaque between children with deciduous dental caries and healthy children

作　　者：孙晓燕 王淑敏 潘湉湉 刘伟伟 姚丽慧 SUN Xiao-yan;WANG Shu-min;PAN Tian-tian;LIU Wei-wei;YAO Li-hui(Center of Stomatology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan,CHINA;Department of Stomatology,the 989th Hospital of the PLA Joint Logistic Support Force,Luoyang 471031,Henan,CHINA;Department of General Stomatology,Zhengzhou Stomatological Hospital,Zhengzhou 450000,Henan,CHINA)

机构地区：[1]郑州大学第一附属医院口腔医学中心,河南郑州450000 [2]中国人民解放军联勤保障部队第九八九医院口腔科,河南洛阳471031 [3]郑州市口腔医院综合科,河南郑州450000

出　　处：《海南医学》2024年第20期2955-2959,共5页Hainan Medical Journal

基　　金：河南省科技攻关项目(编号:202102310595)。

摘　　要：目的分析乳牙龋儿童与健康儿童唾液总分泌型免疫球蛋白A(SIgA)和菌斑主要致龋菌表达的差异性及临床意义。方法选取2021年9月至2023年4月郑州大学第一附属医院收治的300例乳牙龋儿童作为龋病组,选取同期在该院检查的无乳牙龋的健康儿童50例作为对照组。比较两组儿童和乳牙龋病情进展与未进展组儿童的唾液总SIgA、菌斑主要致龋菌表达的差异性,采用二元简单相关性、偏相关性分析唾液总SIgA、主要致龋菌在牙菌斑中的比例与龋病病情进展的关系,采用受试者工作特征(ROC)曲线及曲线下面积(AUC)评估唾液总SIgA、主要致龋菌在牙菌斑中的比例预测龋病病情进展的价值。结果龋病组儿童唾液总SIgA、变形链球菌、远缘链球菌、嗜酸乳杆菌、内氏放线菌在牙菌斑中的比例明显高于对照组,差异均有统计学意义(P<0.05);病情进展组儿童唾液总SIgA、变形链球菌、远缘链球菌、嗜酸乳杆菌、内氏放线菌在牙菌斑中的比例明显高于未进展组,差异均有统计学意义(P<0.05);二元简单相关性分析结果显示,唾液总SIgA、变形链球菌、远缘链球菌、嗜酸乳杆菌、内氏放线菌在牙菌斑中比例与病情进展呈正相关(r=0.822、0.815、0.760、0.794、0.803,P<0.001);偏相关性分析结果显示,唾液总SIgA、主要致龋菌在牙菌斑中比例仍与龋病病情进展显著相关(P<0.001);ROC曲线分析结果显示,唾液总SIgA及变形链球菌、远缘链球菌、嗜酸乳杆菌、内氏放线菌在牙菌斑中的比例联合预测龋病病情进展的AUC为0.924(95%CI:0.875~0.957),明显大于各指标单独预测。结论乳牙龋儿童唾液总SIgA、菌斑主要致龋菌表达与龋病病情进展有关,唾液总SIgA、菌斑主要致龋菌联合预测儿童龋病病情进展的价值较高。Objective To analyze the differences in the expression of total salivary secretory immunoglobulin A(SIgA)and the major cariogenic bacteria in dental plaque between children with primary dental caries and healthy children,as well as their clinical significance.Methods A total of 300 children with primary dental caries admitted to the First Affiliated Hospital of Zhengzhou University from September 2021 to April 2023 were selected as the caries group,and 50 healthy children without primary dental caries who were examined at the same hospital during the same period were selected as the control group.The differences in the total salivary SIgA and the expression of major cariogenic bacteria in dental plaque were compared between the caries group and the control and also between children with and without dental caries progression(progressive group and non-progressive group).The relationship between the total salivary SIgA,the proportion of major cariogenic bacteria in dental plaque,and the progression of dental caries was analyzed using binary simple correlation and partial correlation analysis.The value of the total salivary SIgA and the proportion of major cariogenic bacteria in dental plaque in predicting the progression of dental caries was evaluated by the receiver operating characteristic(ROC)curve and the area under the curve(AUC).Results The proportion of total salivary SIgA,Streptococcus mutans,Streptococcus sobrinus,Lactobacillus acidophilus,and Actinomyces naeslundii in dental plaque in the dental caries group was significantly higher than that in the control group(P<0.05).The proportion of total salivary SIgA,Streptococcus mutans,Streptococcus sobrinus,Lactobacillus acidophilus,and Actinomyces naeslundii in dental plaque was significantly higher in the progressive group than in the non-progressive group(P<0.05).Binary simple correlation analysis showed that the proportion of total salivary SIgA,Streptococcus mutans,Streptococcus sobrinus,Lactobacillus acidophilus,and Actinomyces naeslundii in dental plaque

关 键 词：儿童 龋病 唾液 分泌型免疫球蛋白A 牙菌斑 

分 类 号：R788.1[医药卫生—口腔医学]