Tolerability and first hints for potential efficacy of motor-cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders:A translational viewpoint  

作　　者：Svea-Solveig Mennen Maren Franta Martin Begemann Justus B.H.Wilke Roman Schroder Umer Javed Butt Jonathan-Alexis Cortés-Silva Umut Cakir Marie Gura Markus de Marees Vinicius Daguano Gastaldi Johannes Burtscher Julie Schanz Matthias Bohn Martin Burtscher Andreas Fischer Luise Poustka Peter Hammermann Markus Stadler Fred Luhder Manvendra Singh Klaus-Armin Nave Kamilla Woznica Miskowiak Hannelore Ehrenreich 

机构地区：[1]Clinical Neuroscience,Max Planck Institute for Multidisciplinary Sciences,City Campus,Gottingen,Germany [2]Georg-August-University,Gottingen,Germany [3]Department of Sports Medicine,Ruhr University,Bochum,Germany [4]Institute of Sports Science,University of Lausanne,Lausanne,Switzerland [5]Department of Clinical Chemistry and Interdisciplinary UMG Laboratory,University Medical Center Gottingen,Gottingen,Germany [6]Clinical Pharmacy,Georg-August-University,Gottingen,Germany [7]Faculty of Sports Science,University of Innsbruck,Innsbruck,Austria [8]Department of Child and Adolescent Psychiatry&Psychotherapy,Center for Psychosocial Medicine,University Hospital Heidelberg,Heidelberg,Germany [9]HBL Investmentpartners GmbH,München-Frankfurt,Germany [10]Datico Sport&Health GmbH,Burghausen,Germany [11]Institute for Neuroimmunology and Multiple Sclerosis Research,University Medical Center Gottingen,Gottingen,Germany [12]Department of Neurogenetics,Max Planck Institute for Multidisciplinary Sciences,City Campus,Gottingen,Germany [13]Frederiksberg Hospital and Department of Psychology,Neurocognition and Emotion in Affective Disorders(NEAD)Centre,Copenhagen Affective Disorder Research Centre,Psychiatric Centre Copenhagen,University of Copenhagen,Copenhagen,Denmark [14]Experimental Medicine,Department of Psychiatry and Psychotherapy,Central Institute of Mental Health,Medical Faculty Mannheim,Heidelberg University,Mannheim,Germany

出　　处：《Neuroprotection》2024年第3期228-242,共15页神经保护（英文）

基　　金：ERC Advanced Grant acronym BREPOCI,Grant/Award Number:101054369;ALTIBRAIN,Grant/Award Number:101043416;DFG,Grant/Award Number:TRR-274/12020-408885537。

摘　　要：Hypoxia is more and more perceived as pivotal physiological driving force,allowing cells in the brain and elsewhere to acclimate to lowered oxygen(O_(2)),and abridged metabolism.The mediating transcription program is induced by inspiratory hypoxia but also by intensive motor-cognitive tasks,provoking a relative decrease in O_(2) in relation to the acutely augmented requirement.We termed this fundamental,demand-dependent drop in O_(2) availability"functional hypoxia."Major players in the hypoxia response are hypoxia-inducible factors(HIFs)and associated prolyl-hydroxylases.HIFs are transcription factors,stabilized by low O_(2) accessibility,and control expression of a multitude of genes.Changes in oxygen,however,can also be sensed via other pathways,among them the thiol-oxidase(2-aminoethanethiol)dioxygenase.Considering the far-reaching biological response to hypoxia,hitherto mostly observed in rodents,we initiated a translational project,combining mild to moderate inspiratory with functional hypoxia.We had identified this combination earlier to benefit motor-cognitive attainment in mice.A total of 20 subjects were included:13 healthy individuals and 7 patients with depression and/or autism spectrum disorder.Here,we show that motor-cognitive training under inspiratory hypoxia(12%O_(2))for 3.5 h daily over 3 weeks is optimally tolerated.We present first signals of beneficial effects on general well-being,cognitive performance,physical fitness and psychopathology.Erythropoietin in serum increases under hypoxia and flow cytometry analysis of blood reveals several immune cell types to be mildly modulated by hypoxia.To obtain reliable information regarding the"add-on"value of inspiratory on top of functional hypoxia,induced by motor-cognitive training,a single-blind study—with versus without inspiratory hypoxia—is essential and outlined here.

关 键 词：brain cognition ERYTHROPOIETIN functional hypoxia high-parameter flow cytometry immune cells oxygen saturation physical fitness plasticity 

分 类 号：R741[医药卫生—神经病学与精神病学]