PRPF8与肿瘤关系的研究进展  

Research Progress on the Relationship Between PRPF8 and Cancer

作　　者：黄国庆[1] 薛佳莹[1] 王丹丹 Huang Guoqing;Xue Jiaying;Wang Dandan(Department of Biotechnology,Institute of Advanced Technology,Heilongjiang Academy of Sciences,Harbin 150020,China)

机构地区：[1]黑龙江省科学院高技术研究院生物技术研究室,哈尔滨150020

出　　处：《黑龙江科学》2024年第20期131-135,共5页Heilongjiang Science

基　　金：黑龙江省科学院杰青项目(JQ2024GJS01);黑龙江省科学院预研项目(YY2022GJS01);黑龙江省院所基本科研业务费项目(ZNBZ2022GJS04);黑龙江省自然科学基金项目(LH2021H056)。

摘　　要：PRPF8作为可变剪接过程中不可或缺的剪接体的关键元件,能与U5 snRNP及5’、3’剪接位点发生相互作用,促进剪接体的组装,参与可变剪接过程中的多个关键步骤。PRPF8的异常将导致包括癌症在内的多种生理或病理性疾病的产生。综述了PRPF8基本结构功能,总结了PRPF8在多种癌症中的作用,展望了其在临床治疗上的应用前景。PRPF8 encodes the catalytic center in the alternative splicing process,which can interact with U5 snRNP and 5’and 3’splicing sites,promote the assembly of spliceosomes,and participate in multiple key steps in the alternative splicing process.The abnormity of PRPF8 will lead to the development of many physiological or pathological diseases,including cancer.The study reviews the basic structure and function of PRPF8,summarizes the relationship between PRPF8 and various cancers,and prospects the application prospect in clinics.

关 键 词：PRPF8 可变剪接 肿瘤 

分 类 号：R730.4[医药卫生—肿瘤]