晚期喉癌药物治疗的研究进展  

Research progress of drug therapy for advanced laryngeal cancer

作　　者：张西 邓启成 赵锐[3] 刘海[3] ZHANG Xi;DENG Qicheng;ZHAO Rui;LIU Hai(Department of Otolaryngology Head and Neck Surgery,Nanchong Central Hospital,the Second Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Public Health Clinical Center of Chengdu,Chengdu 610066,China;Department of Otolaryngology Head and Neck Surgery,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院第二临床医学院南充市中心医院耳鼻咽喉头颈外科,四川南充637000 [2]成都公共卫生临床医疗中心,四川成都610066 [3]川北医学院附属医院耳鼻咽喉头颈外科,四川南充637000

出　　处：《中国耳鼻咽喉颅底外科杂志》2024年第5期122-126,共5页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：四川省医学科研课题计划项目(S19055)。

摘　　要：喉癌是头颈部最常见的恶性肿瘤之一,大多数喉癌患者在确诊时已经处于晚期,预后通常较差,虽然切除全喉的手术治疗配合高强度放射治疗为喉癌患者提供了癌症治愈的机会,但切除全喉后可能导致患者失去语音能力、改变呼吸通道等,严重影响患者的生活质量。随着国内外喉癌治疗的不断深入研究,新的治疗技术如诱导化疗、放化同步治疗和生物治疗已经相继问世。本文通过对用于喉癌治疗的药物进行了综述,旨在为临床治疗提供借鉴。Laryngeal cancer is one of the most common malignant tumors of the head and neck.Most laryngeal cancer patients are diagnosed at an advanced stage and the prognosis is usually poor.Although total laryngectomy combined with high-intensity radiotherapy provides a cure opportunity for laryngeal cancer patients,total laryngectomy may lead to loss of speech ability and change of breathing channels,etc.,which seriously affects the quality of life of patients.With the continuous in-depth research on the treatment of laryngeal cancer at home and abroad,new treatment techniques such as induction chemotherapy,concurrent chemoradiotherapy and biological therapy have been developed.The purpose of this paper is to review the drugs used in the treatment of laryngeal cancer and provide reference for clinical treatment.

关 键 词：喉癌 喉保留 细胞毒性药物 靶向治疗 免疫治疗 

分 类 号：R739.65[医药卫生—肿瘤]