脑深部电刺激术治疗帕金森病的机制和靶点选择新进展  

New progress in the mechanism and target selection research of deep brain stimulation for the treatment of Parkinson's disease

作　　者：谢东 郭鹏航 张佳南 高宇 赵全堂 张致晨 周杰 XIE Dong;GUO Penghang;ZHANG Jianan;GAO Yu;ZHAO Quantang;ZHANG Zhichen;ZHOU Jie(Department of Neurosurgery,The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Lanzhou,Gansu 730000,China;Department of First Clinical College of Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730030,China;Graduate School of Ningxia Medical University,Yinchuan,Ningxia 750000,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院神经外科,甘肃兰州730000 [2]甘肃中医药大学第一临床医学院,甘肃兰州730030 [3]宁夏医科大学研究生院,宁夏银川750000

出　　处：《中华神经外科疾病研究杂志》2024年第6期85-89,共5页Chinese Journal of Neurosurgical Disease Research

基　　金：甘肃省自然科学基金(23JRRA532);兰州市科技局科技计划项目(2023-ZD-167)。

摘　　要：帕金森病(Parkinson's disease,PD)是一种严重进行性神经退行性疾病,既有运动症状也有非运动症状,其病症严重影响着人们的生活。深部脑刺激(deep brain stimulation,DBS)是一种公认的安全的神经外科对症疗法,适用于内科治疗无法充分控制的症状或多巴胺能药物引起运动障碍等严重副作用的晚期疾病患者。DBS领域的进步,包括技术、机制理解和应用,有可能扩大DBS的获取和使用,同时也改善临床结局。在这篇综述中,我们总结了近年来最新研究机制、靶点选择以及DBS治疗新进展。Parkinson's disease(PD)is a severe progressive neurodegenerative disorder with both motor and non-motor symptoms.Deep brain stimulation(DBS)is a recognized and safe neurosurgical symptomatic therapy for patients with advanced disease whose symptoms cannot be adequately controlled by medical therapy or whose dopaminergic medications cause severe side effects such as dyskinesia.Advances in the field of DBS,including technology,mechanistic understanding and application,have the potential to expand access to,and the use of,DBS,as well as improving clinical outcomes.This review summarizes the latest research in the mechanisms,target selection,and progress in the treatment of DBS in recent years.

关 键 词：帕金森病 脑深部电刺激术 机制 靶点 治疗 

分 类 号：R742.5[医药卫生—神经病学与精神病学]