铜死亡相关基因CDKN2A对头颈部鳞状细胞癌预后及药物敏感性分析  

Prognosis and Drug Sensitivity of Cuproptosis-related Gene CDKN2A in Head and Neck Squamous Cell Carcino⁃ma

作　　者：童琰 刘雅丽 TONG Yan;LIU Ya-li(Department of Oncology,Xiangyang No.1 People′s Hospital,Hubei University of Medicine,Xiangyang,Hubei 442000,China;Department of Otolaryngology,Xiangyang No.1 People′s Hospital,Hubei University of Medicine,Xiangyang,Hubei 442000,China)

机构地区：[1]湖北医药学院附属襄阳市第一人民医院肿瘤科,湖北襄阳442000 [2]湖北医药学院附属襄阳市第一人民医院耳鼻喉科,湖北襄阳442000

出　　处：《湖北医药学院学报》2024年第5期483-489,共7页Journal of Hubei University of Medicine

基　　金：襄阳市科技研究与开发项目(2020ZD33)。

摘　　要：目的:筛选头颈部鳞状细胞癌预后相关的铜死亡相关基因并对其进行药物敏感性分析。方法:通过对TCGA数据库中的HNSCC样本进行突变基因筛选,挑选出铜死亡相关基因并对其进行药物敏感与耐药分析。结果:在23个HNSCC突变率10%及以上的基因中,CDKN2A、CSMD3和RYR2为HNSCC突变关键基因。13个铜死亡相关基因中,CDKN2A、GLS和ATP7B为预后相关的关键基因。对HNSCC中CDKN2A基因敏感的药物包括Thapsi⁃gargin、ACY-1215(Rocilinostat)和Trichostatin A,有较高抵抗的药物包括Palbociclib、Nutlin-3a、Platin、SJ-172550、carbazochrome和bambuterol。结论:铜死亡相关基因CDKN2A与HNSCC的5年生存率高度相关,并且可能对抗肿瘤药物Thapsigargin、ACY-1215(Rocilinostat)和Trichostatin A敏感。Objective To identify cuproptosis-related genes associated with prognosis in head and neck squamous cell carci⁃noma(HNSCC)and analyze their drug sensitivity.Methods Mutant genes in HNSCC samples obtained from the TCGA da⁃tabase were screened to select cuproptosis-related genes for drug sensitivity and resistance analysis.Results Among the 23 genes with a mutation rate of 10%or above in HNSCC,CDKN2A,CSMD3,and RYR2 were identified as key genes.Among the 13 cuproptosis-related genes,CDKN2A,GLS,and ATP7B were identified as key genes associated with prognosis.Drugs sensitive to the CDKN2A in HNSCC included Thapsigargin,ACY-1215(Rocilinostat),and Trichostatin A,while drugs with high resistance included Palbociclib,Nutlin-3a,Platin,SJ-172550,carbazochrome,and bambuterol.Conclu⁃sion CDKN2A is highly correlated with the 5-year survival of HNSCC and is sensitive to anti-tumor drugs Thapsigargin,ACY-1215(Rocilinostat),and Trichostatin A.

关 键 词：铜死亡 头颈部鳞状细胞癌 CDKN2A 

分 类 号：R739.91[医药卫生—肿瘤]