氟哌噻吨美利曲辛辅助治疗难治性非糜烂性胃食管反流病的临床效果分析  

Clinical Effect of Flupentixol and Melitracen in the Adjuvant Treatment of Refractory Non-erosive Gastroesophageal Reflux Disease

作　　者：孙兆伦 Sun Zhaolun(Jinan Laiwu District Chayekou Town Health Center,Jinan 271100,Shandong Province,China)

机构地区：[1]济南市莱芜区茶业口镇卫生院,山东济南271100

出　　处：《中国社区医师》2024年第27期31-33,共3页Chinese Community Doctors

摘　　要：目的:探讨氟哌噻吨美利曲辛辅助治疗难治性非糜烂性胃食管反流病的临床效果。方法:选取2023年3月—2024年6月于济南市莱芜区茶业口镇卫生院就诊的100例难治性非糜烂性胃食管反流病患者作为研究对象,采用随机数字表将其分为观察组和对照组,各50例。对照组实施常规治疗,观察组在对照组基础上给予氟哌噻吨美利曲辛辅助治疗。观察两组临床症状评分、心理状态、治疗效果、不良反应及生活质量。结果:治疗后,两组反流、胸骨后疼痛、胃灼热、反酸、焦虑自评量表及抑郁自评量表评分均低于治疗前,且观察组低于对照组(P<0.05)。观察组治疗总有效率高于对照组(P=0.012)。两组不良反应总发生率比较,差异无统计学意义(P=0.727)。治疗后,两组心理功能、社会功能、躯体功能、健康状况评分均高于治疗前,且观察组高于对照组(P<0.05)。结论:氟哌噻吨美利曲辛辅助治疗难治性非糜烂性胃食管反流病的应用效果较好,可改善患者的临床症状和心理状态,提高生活质量,且安全性较高。Objective:To investigate the clinical effect of flupentixol and melitracen in the adjuvant treatment of refractory non-erosive gastroesophageal reflux disease.Methods:A total of one hundred patients with refractory non-erosive gastroesophageal reflux disease who were treated in Jinan Laiwu District Chayekou Town Health Center from March 2023 to June 2024 were selected as the study objects,and were divided into observation group and control group by random number table,with fifty cases in each group.The control group received conventional treatment,and the observation group received adjuvant treatment with flupentixol and melitracen on the basis of the control group.The clinical symptom score,psychological state,therapeutic effect,adverse reactions and quality of life of the two groups were observed.Results:After treatment,the scores of reflux,retrosternal pain,heartburn,acid reflux,self-rating anxiety scale and self-rating depression scale in both groups were lower than before treatment,and the observation group was lower than the control group(P<0.05);the total effective rate of observation group was higher than that of control group(P=0.012);there was no significant difference in the total incidence of adverse reactions between the two groups(P=0.727);after treatment,the scores of mental function,social function,physical function and health status of the two groups were higher than before treatment,and the observation group was higher than the control group(P<0.05).Conclusion:The application of flupentixol and melitripen in the adjuvant treatment of refractory non-erosive gastroesophageal reflux disease has a good effect,can improve the clinical symptoms and psychological state of patients,improve the quality of life,and has a high safety.

关 键 词：难治性非糜烂性胃食管反流病 氟哌噻吨美利曲辛 心理状态 

分 类 号：R571[医药卫生—消化系统]