过渡金属催化芳香碳环的选择性不对称氢化  

Transition Metal Catalyzed Carbocycle-Selective Asymmetric Hydrogenation of Aromatic Rings

作　　者：陈倩[1,2] 韩召斌[2] 丁奎岭[2,3,4] Chen Qian;Han Zhaobin;Ding Kuiling(School of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai 200093;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032;School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240;Frontiers Science Center for Transformative Molecules,Shanghai Jiao Tong University,Shanghai 200240)

机构地区：[1]上海理工大学材料与化学学院,上海200093 [2]中国科学院上海有机化学研究所、金属有机化学国家重点实验室,上海200032 [3]上海交通大学化学化工学院,上海200240 [4]上海交通大学变革性分子前沿科学中心,上海200240

出　　处：《有机化学》2024年第7期2063-2076,共14页Chinese Journal of Organic Chemistry

基　　金：国家重点研发计划(No.2021YFA1500200);国家自然科学基金(No.21872167);上海市优秀学术/技术带头人计划(No.22XD1424800)资助项目。

摘　　要：(杂)芳烃中碳环的不对称氢化是制备饱和以及部分饱和手性六元碳环化合物最直接高效的方法之一.尽管(杂)芳烃的不对称氢化在反应活性、选择性等方面存在着很大的挑战,但近年来该领域还是取得了一些突破.系统地综述了过去几十年过渡金属催化的芳烃中碳环不对称氢化的研究进展,并讨论了该领域存在的问题及可能的发展方向.Asymmetric hydrogenation of carbon rings in(hetero)arenes is one of the most direct and efficient methods for preparing saturated and partially saturated chiral six membered carbon ring compounds.While significant challenges in terms of low reactivity and selectivity remain,some breakthroughs have been made in this field of carbocycle-selective asymmetric hydrogenation of(hetero)arenes in recent years.The research progress of transition metal catalyzed carbocycle-selective asymmetric hydrogenatiorospects of further developments are also discussed.

关 键 词：过渡金属 (杂)芳烃 不对称氢化 去芳构化 

分 类 号：O621.251[理学—有机化学]