原发性肝癌组织CCR7、MCM10蛋白与临床病理特征及预后的相关性  

Correlation Between CCR7 and MCM10 Proteins in Primary Liver Cancer Tissue and Clinical Pathological Characteristics and Prognosis

作　　者：卜晓红[1] 陈秋明 张学振 卢锋[3] BU Xiaohong;CHEN Qiuming;ZHANG Xuezhen;LU Feng(Department of Pathology,Zhoukou Central Hospital,Zhoukou 466000,China;Department of Infectious Disease,Zhoukou Central Hospital,Zhoukou 466000,China;Beijing Jiuqiang Biotechnology Co.,LTD.,Beijing 100000,China)

机构地区：[1]周口市中心医院病理科,河南周口466000 [2]北京九强生物技术股份有限公司,河南周口466000 [3]周口市中心医院感染科,北京100000

出　　处：《河南医学研究》2024年第20期3711-3716,共6页Henan Medical Research

基　　金：国家重点研发计划(2022YFF0710301)。

摘　　要：目的 探讨原发性肝癌(PHC)组织趋化因子受体7(CCR7)、微染色体维持蛋白10(MCM10)与临床病理特征及预后的相关性。方法 选取2017年1月至2020年12月周口市中心医院90例PHC患者为研究对象,均行肝癌切除术,术中取肿瘤组织及癌旁正常组织。比较PHC不同组织CCR7、MCM10蛋白表达,χ^(2)检验分析CCR7、MCM10表达与临床病理特征的关系,Kaplan-Meier分析CCR7、MCM10蛋白表达与PHC患者预后的关系,Cox回归分析PHC患者预后影响因素,Kaplan-Meier分析CCR7、MCM10蛋白表达亚组与PHC患者预后的关系。结果 PHC患者肿瘤组织中CCR7、MCM10蛋白阳性表达分别为66.67%、75.56%,高于正常组织的23.33%、27.78%,差异有统计学意义(P<0.05);有淋巴结转移、血管侵犯患者癌组织中CCR7、MCM10蛋白阳性表达率(79.25%、94.34%,81.58%、89.47%)高于无淋巴结转移、血管侵犯患者(48.65%、48.65%,55.77%、65.38%),差异有统计学意义(P<0.05);Kaplan-Meier生存分析显示,CCR7、MCM10蛋白阳性表达患者的3 a生存率分别为39.66%(23/58)、41.54%(27/65),低于阴性表达患者的68.97%(20/29)、72.73%(16/22),差异有统计学意义(P<0.05);Cox回归分析显示,淋巴结转移(95%CI:1.129~3.025)、血管侵犯(95%CI:1.463~3.147)、CCR7蛋白(95%CI:1.407~3.524)、MCM10蛋白(95%CI:1.384~3.441)均为PHC患者预后的独立危险因素(P<0.05);Kaplan-Meier分析显示,CCR7蛋白阳性+MCM10蛋白阳性亚组预后最差,CCR7蛋白阴性+MCM10蛋白阴性亚组预后最好,各亚组间比较差异均有统计学意义(P<0.05)。结论 PHC组织CCR7、MCM10蛋白表达与临床病理特征及预后相关,二者均阳性表达是预后不良的危险因素,可作为临床评估病情、预测预后的辅助指标,并对临床防治具有一定指导意义。Objective To explore the correlation between chemokine receptor 7(CCR7)and microsomal maintenance protein 10(MCM10)in primary liver cancer(PHC)tissue and clinical pathological characteristics and prognosis.Methods A total of 90 patients with PHC in Zhoukou Central Hospital from January 2017 to December 2020 were selected as the study objects.All patients underwent hepatocellular carcinoma resection,and tumor tissues and adjacent normal tissues were taken during the operation.The expression of CCR7 and MCM10 protein in different PHC tissues was compared,χ^(2) test was used to analyze the relationship between CCR7 and MCM10 expression and clinicopathological features,Kaplan-Meier analysis was used to analyze the relationship between CCR7 and MCM10 protein expression and prognosis of PHC patients,and Cox regression analysis was used to analyze the influencing factors of prognosis of PHC patients.Kaplan-Meier analysis was used to analyze the relationship between the expression subgroups of CCR7 and MCM10 protein and the prognosis of patients with PHC.Results The positive expressions of CCR7 and MCM10 protein in PHC patients were 66.67%and 75.56%,respectively,significantly higher than those in normal tissues(23.33%and 27.78%),with statistical significance(P<0.05).The positive expression rates of CCR7 and MCM10 protein in cancer tissues of patients with lymph node metastasis and vascular invasion(79.25%,94.34%and 81.58%,89.47%)were higher than those of patients without lymph node metastasis and vascular invasion(48.65%,48.65%and 55.77%,65.38%),the differences were statistically significant(P<0.05).Kaplan-Meier survival analysis showed that the 3-year survival rates of patients with positive expression of CCR7 protein and MCM10 protein were 39.66%(23/58)and 41.54%(27/65),respectively,which were significantly lower than those of patients with negative expression of CCR7 protein,68.97%(20/29)and 72.73%(16/22),the differences were statistically significant(P<0.05).Cox regression analysis showed that lymph node metastasis(

关 键 词：原发性肝癌 趋化因子受体7 微染色体维持蛋白10 临床病理特征 预后 相关性 

分 类 号：R735.7[医药卫生—肿瘤]