TRPS1在滑膜肉瘤诊断和鉴别诊断中的价值  

Value of TRPS1 in diagnosis and differential diagnosis of synovial sarcoma

作　　者：刘一靖[1] 王晓娟[1] 李志文 陈岚[1] 张勇峰 黄文斌 LIU Yijing;WANG Xiaojuan;LI Zhiwen;CHEN Lan;ZHANG Yongfeng;HUANG Wenbin(Department of Pathology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China;Department of Pathology,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210009,China)

机构地区：[1]河南科技大学第一附属医院病理科,洛阳471003 [2]南京大学附属南京鼓楼医院病理科,南京210009

出　　处：《临床与实验病理学杂志》2024年第10期1064-1067,1074,共5页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨单克隆和多克隆TRPS1抗体在滑膜肉瘤中的表达,分析其在滑膜肉瘤诊断和鉴别诊断中的价值以及多克隆TRPS1抗体诊断滑膜肉瘤的敏感度和特异度。方法应用免疫组化EnVision法检测单克隆和多克隆TRPS1抗体在滑膜肉瘤及拟似滑膜肉瘤病变中的表达。结果31例滑膜肉瘤中,单克隆和多克隆TRPS1抗体的阳性率分别为54.8%和93.5%;30例拟似滑膜肉瘤病变中,多克隆TRPS1抗体阳性2例,阳性率为6.67%,多克隆TRPS1抗体在滑膜肉瘤中的阳性率明显高于拟似滑膜肉瘤病例,差异有统计学意义(P<0.05)。多克隆TRPS1抗体诊断滑膜肉瘤的敏感度为93.5%,特异度为93.3%。结论多克隆TRPS1抗体对滑膜肉瘤的诊断具有较高的敏感度和特异度,在日常病理诊断中推荐使用多克隆TRPS1抗体。Purpose To study the expression of of monoclonal and polyclonal TRPS1 antibodies in synovial sarcoma,and to explore the value of TRPS1 in the diagnosis and differential diagnosis of synovial sarcoma and the sensitivity and specificity of polyclonal TRPS1 for the diagnosis of synovial sarcoma.Methods Immunohistochemical EnVision method was used to detect the expression of monoclonal and polyclonal TRPS1 antibodies in the synovial sarcomas and its mimickers.Results Among 31 cases of synovial sarcoma,the positive rates of polyclonal and monoclonal TRPS1 antibodies were 54.8%and 93.5%,respectively.Of 30 synovial sarcoma mimicking lesions,2 were positive for TRPS1(polyclonal antibody),which was 6.67%,and TRPS1 was more frequently expressed in synovial sarcoma than in non-synovial sarcoma(P<0.05).The sensitivity of polyclonal TRPS1 antibody for the diagnosis of synovial sarcoma was 93.5%,and the specificity was 93.3%.Conclusion Polyclonal TRPS1 antibody has a higher sensitivity and specificity for the diagnosis of synovial sarcoma and it therefore is recommended in routine pathologic diagnosis.

关 键 词：滑膜肉瘤 TRPS1 拟似病变 诊断 

分 类 号：R738.5[医药卫生—肿瘤]