地夸磷索钠滴眼液和环孢素滴眼液治疗飞秒激光小切口角膜基质透镜取出术(SMILE)后干眼的疗效对比分析  

Comparison of the efficacy of diquafosol sodium eye drops and cyclosporine eye drops in the treatment of dry eye after femtosecond laser small incision lenticule extraction

作　　者：杜婧 曹宁 高燕 张佳 田媛媛 李勇 李晶 李娟 魏升升 鱼喆 高金荣 DU Jing;CAO Ning;GAO Yan;ZHANG Jia;TIAN Yuanyuan;LI Yong;LI Jing;LI Juan;WEI Shengsheng;YU Zhe;GAO Jinrong(Shaanxi Eye Hospital,Xi’an People’s Hospital(Xi’an Fourth Hospital),Xi’an 710004,Shaanxi Province,China)

机构地区：[1]西安市人民医院(西安市第四医院),陕西省眼科医院,陕西省西安市710004

出　　处：《眼科新进展》2024年第11期887-890,897,共5页Recent Advances in Ophthalmology

基　　金：陕西省科学技术厅一般项目社会发展领域(编号:2023YBSF586);陕西省科学技术厅一般项目(编号:2024SF-YBXM-334);陕西省自然科学基础研究计划面上项目(编号:2017JM8043);西安市卫生健康委员会一般研究项目(编号:2020yb11);西安市人民医院(西安市第四医院)科研孵化基金项目(编号:FZ-84)。

摘　　要：目的对30 g·L^(-1)地夸磷索钠滴眼液和0.5 g·L^(-1)环孢素滴眼液治疗飞秒激光小切口角膜基质透镜取出术(SMILE)后干眼的疗效进行对比分析。方法选取2024年1月至2月于西安市第四医院行SMILE的患者37例74眼作为研究对象;采用随机数字表法将患者随机分为3组:环孢素组11例,地夸磷素钠组16例,对照组10例。三组患者年龄、性别差异均无统计学意义(均为P>0.05)。环孢素组患者给予0.5 g·L^(-1)环孢素滴眼液治疗,每天滴眼2次,每次1滴,持续治疗3个月。地夸磷索钠组患者给予30 g·L^(-1)地夸磷素钠滴眼液治疗,每天滴眼6次,每次1滴,持续治疗3个月。对照组患者给予玻璃酸钠滴眼液治疗,每天滴眼3次,每次1滴,可根据临床症状调整滴眼次数,持续治疗3个月。所有患者于术后1个月及3个月来院复查,获得患者视力、眼压、眼红评分(R-Scan)、泪液分泌实验(SIT)、非侵入式泪膜破裂时间(NIBUT)、眼表疾病指数评分(OSDI)等指标。采用SPSS 22.0统计学软件进行数据分析,比较三组患者术前、术后1个月及3个月的视力、眼压、R-Scan、SIT、NIBUT、OSDI等6项指标。结果结果显示,环孢素组患者术后1个月及3个月眼压均较术前降低;术后3个月NIBUT较术前延长;术后1个月及3个月OSDI均较术前升高,差异均有统计学意义(均为P<0.05)。地夸磷索钠组患者术后1个月及3个月眼压均较术前降低;术后3个月SIT较术前减小;术后1个月OSDI均较术前及术后3个月升高,差异均有统计学意义(均为P<0.05)。对照组患者术后1个月及3个月眼压均较术前降低,术后3个月的裸眼视力优于术前最佳矫正视力,差异均有统计学意义(均为P<0.05)。术后1个月及3个月三组患者的视力、眼压、R-Scan组间比较,差异均无统计学意义(均为P>0.05)。术后1个月,对照组患者SIT、NIBUT均高于环孢素组和地夸磷索钠组,差异均有统计学意义(均为P<0.05);地夸磷索钠组患Objective To compare the efficacy of 30 g·L^(-1) diquafosol sodium eye drops and 0.5 g·L^(-1) cyclosporine eye drops in patients with dry eye after femtosecond laser small incision lenticule extraction(SMILE).Methods A total of 37 patients(74 eyes)undergoing SMILE in Xi’an Fourth Hospital from January to February 2024 were selected as the subjects.Patients were randomly divided into the cyclosporine group(11 patients),diquafosol sodium group(16 patients),and control group(10 patients)through a random number table method.There were no significant differences in the age and gender of patients in the three groups(both P>0.05).Patients in the cyclosporine group were treated with 0.5 g·L^(-1) cyclosporine eye drops,twice a day,1 drop each time,for 3 months.Patients in the diquafosol sodium group were treated with 30 g·L^(-1) diquafosol sodium eye drops,6 times a day,1 drop each time,for 3 months.Patients in the control group were treated with sodium hyaluronate eye drops,3 times a day,1 drop each time,for 3 months,and the frequency of administration could be adjusted according to clinical symptoms.The visual acuity,intraocular pressure,redness scan(R-Scan),Schirmer tear test(SIT),non-invasive break-up time(NIBUT)and ocular surface disease index(OSDI)questionnaire scores were measured in all patients at 1 month and 3 months after the operation.SPSS 22.0 statistical software was used for data analysis,and visual acuity,intraocular pressure,R-Scan,SIT,NIBUT and OSDI scores were compared among the three groups before,1 month and 3 months after the operation.Results In the cyclosporine group,intraocular pressures of patients at 1 month and 3 months postoperatively were significantly lower than the preoperative level;the NIBUT was significantly prolonged at 3 months after operation compared with the preoperative level;OSDI scores were significantly elevated at both 1 month and 3 months postoperatively compared with the preoperative level(all P<0.05).In the diquafosol sodium group,intraocular pressure at 1 month and 3

关 键 词：环孢素滴眼液 地夸磷索钠滴眼液 飞秒激光小切口角膜基质透镜取出术 干眼 

分 类 号：R778[医药卫生—眼科]