FAP靶向分子影像探针在疾病检测中的研究进展  

Advances in FAP-targeted molecular imaging probes for disease detection

作　　者：王潇 许晓平 宋少莉[1,2,3,4] WANG Xiao;XU Xiaoping;SONG Shaoli(Department of Nuclear Medicine,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Center for Biomedical Imaging,Fudan University,Shanghai 200032,China;Shanghai Engineering Research Center of Molecular Imaging Probes,Shanghai 200032,China;Key Laboratory of Nuclear Physics and Ion-beam Application(MOE),Fudan University,Shanghai 200433,China)

机构地区：[1]复旦大学附属肿瘤医院核医学科,复旦大学上海医学院肿瘤学系,上海200032 [2]复旦大学生物医学影像研究中心,上海200032 [3]上海分子影像探针工程技术研究中心,上海200032 [4]核物理与离子束应用教育部重点实验室,复旦大学,上海200433

出　　处：《肿瘤影像学》2024年第5期457-469,共13页Oncoradiology

基　　金：国家自然科学基金重点项目(U23A20465)。

摘　　要：核医学分子影像技术凭借其无创性和高灵敏度的特点被广泛应用于肿瘤、神经系统疾病、心血管疾病等的诊断。成纤维细胞活化蛋白(fibroblast activation protein,FAP)是一种Ⅱ型丝氨酸蛋白酶,其在90%的恶性实体瘤中高表达。目前以FAP为靶点,已经开发了多种FAP抑制剂(FAP inhibitor,FAPI),其中大多数都具有纳摩尔水平的FAP亲和力以及高FAP选择性,应用于肿瘤的正电子发射体层成像(positron emission tomography,PET)/计算机体层成像(computed tomography,CT)。此外,FAP还在活化的成纤维细胞中高表达,有部分学者探究了FAPI PET/CT在非肿瘤疾病中的应用价值。本文将针对于FAP靶向分子影像探针以及在肿瘤疾病和非肿瘤疾病中的研究进展进行述评。The molecular imaging technology of nuclear medicine is widely used in the diagnosis of tumors,neurological diseases,cardiovascular diseases and other diseases due to its non-invasiveness and high sensitivity.Fibroblast Activation Protein(FAP)is a typeⅡserine protease that is highly expressed in 90%of malignant solid tumors.A variety of FAP inhibitors(FAPI)have been developed to target FAP,most of which have nanomolar levels of FAP affinity as well as high FAP selectivity for positron emission tomography(PET)/computed tomography(CT)imaging of tumors.In addition to this,FAP is also highly expressed in activated fibroblasts,and some scholars have explored the value of FAPI PET/CT in non-tumor diseases.In this paper,we reviewed the progress of FAP-targeted molecular imaging probes and research in oncologic and non-oncologic diseases.

关 键 词：成纤维细胞活化蛋白抑制剂 正电子发射体层成像/计算机体层成像 分子影像 核医学 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]