红金消结浓缩丸联合米非司酮对多发性子宫肌瘤腹腔镜切除术后疗效的影响  

Impact of Hongjin Xiaojie Concentrated Pills combined with mifepristone on the efficacy after laparoscopic resection of multiple uterine leiomyomas

作　　者：王冰玉[1] 胡俊攀 孙艳敏 傅金英[2] WANG Bing-yu;HU Jun-pan;SUN Yan-min;FU Jin-ying(Department of Obstetrics and Gynecology,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450003,Henan,China)

机构地区：[1]河南省中医院妇产科,河南郑州450003 [2]河南中医药大学第二附属医院妇科,河南郑州450003

出　　处：《广东医学》2024年第10期1283-1288,共6页Guangdong Medical Journal

基　　金：河南省中医药科学研究专项课题(2022ZY1082)。

摘　　要：目的探讨红金消结浓缩丸联合米非司酮对多发性子宫肌瘤腹腔镜切除术后疗效和患者血清性激素、转化生长因子-β1(TGF-β1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)水平的影响。方法选择2020年6月至2022年6月收治的124例多发性子宫肌瘤患者作为研究对象,按随机数字表法分为两组,每组62例。所有患者均接受腹腔镜子宫肌瘤剔除术(LM)治疗,其中观察组于术后联合使用红金消结浓缩丸和米非司酮治疗,对照组术后单用米非司酮治疗。连续治疗3个月后,比较两组临床疗效。治疗前后检测患者血清性激素[雌二醇(E_(2))、促卵泡生成素(FSH)、促黄体生成素(LH)]水平以及TGF-β1、IGFBP-3水平。统计两组不良反应情况。术后对所有患者进行至少12个月的追踪随访,比较两组术后6、12个月复发情况。结果观察组总有效率为98.39%(61/62),与对照组的87.10%(54/62)相比显著升高(P<0.05)。两组治疗后血清E_(2)、FSH、LH、TGF-β1水平均较治疗前显著降低(P<0.05),血清IGFBP-3水平均较治疗前显著升高(P<0.05);治疗后,观察组血清E_(2)、FSH、LH、TGF-β1水平均显著低于对照组(P<0.05),血清IGFBP-3水平显著高于对照组(P<0.05)。观察组术后6、12个月复发率分别为1.61%、4.84%,对照组分别为6.45%、16.13%;术后12个月,观察组复发率显著低于对照组(P<0.05)。观察组不良反应发生率为6.45%,对照组为14.52%,两组比较差异无统计学意义(P>0.05)。结论于多发性子宫肌瘤LM术后联合应用红金消结浓缩丸和米非司酮治疗能有效调节血清性激素及TGF-β1、IGFBP-3水平,提高临床疗效,减少术后复发。Objective To explore the efficacy of Hongjin Xiaojie Concentrated Pills combined with mifepristone on patients following laparoscopic resection of multiple uterine leiomyomas,as well as their effects on serum sex hormone levels,transforming growth factor-β1(TGF-β1),and insulin-like growth factor binding protein-3(IGFBP-3).Methods A total of 124 patients with multiple uterine leiomyomas who were treated in our hospital from June 2020 to June 2022 were selected for this study.The patients were randomly divided into two groups of 62 each.All patients underwent laparoscopic myomectomy(LM).The observation group received combined treatment with Hongjin Xiaojie Concentrated Pills and mifepristone postoperatively,while the control group received only mifepristone.After three months of continuous treatment,clinical efficacy was compared between the two groups.Serum sex hormone levels(estradiol[E_(2)],follicle-stimulating hormone[FSH],luteinizing hormone[LH]),as well as TGF-β1 and IGFBP-3 levels,were measured before and after treatment.The incidence of adverse reactions was recorded,and all patients were followed up for at least 12 months to compare recurrence rates at 6 and 12 months postoperatively.Results The total effective rate in the observation group was 98.39%(61/62),significantly higher than the 87.10%(54/62)in the control group(P<0.05).After treatment,serum levels of E_(2),FSH,LH,and TGF-β1 significantly decreased in both groups(P<0.05),while IGFBP-3 levels significantly increased(P<0.05).Post-treatment,the observation group had significantly lower serum levels of E_(2),FSH,LH,and TGF-β1,and significantly higher IGFBP-3 levels compared to the control group(P<0.05).The recurrence rates at 6 and 12 months post-surgery in the observation group were 1.61%and 4.84%,respectively,compared to 6.45%and 16.13%in the control group;the observation group had a significantly lower recurrence rate at 12 months(P<0.05).The incidence of adverse reactions in the observation group was 6.45%,while it was 14.52%in the control gr

关 键 词：红金消结浓缩丸 米非司酮 多发性子宫肌瘤 腹腔镜 转化生长因子-β1 胰岛素样生长因子结合蛋白-3 

分 类 号：R737.33[医药卫生—肿瘤] R711.6[医药卫生—临床医学]