液相色谱串联质谱技术在治疗药物监测中的应用进展  

Advances in the application of liquid chromatography tandem mass spectrometry for therapeutic drug monitoring

作　　者：刘洁欣 郭玮 Liu Jiexin;Guo Wei(Department of Clinical Laboratory Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院检验科,上海200032

出　　处：《中华预防医学杂志》2024年第10期1604-1609,共6页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金面上项目(82172348);上海市临床重点专科建设项目(shslczdzk03302)。

摘　　要：对治疗药物进行监测是个体化医疗的良好诠释,有助于提高患者用药的安全性和有效性。液相色谱串联质谱技术因其特异性强、灵敏度高、方法开发灵活性好的特点,逐渐被临床实验室接受,并广泛用于治疗药物监测。本文介绍了治疗药物监测的重要性和分析技术,阐述液相色谱串联质谱在治疗药物监测的应用和发展、不同药物类型和样本类型检测的新进展,以及在自动化、便捷化和标准化面临的挑战。Therapeutic drug monitoring is a good interpretation of personalized medicine,which helps to improve the safety and effectiveness of patient medication.Liquid chromatography-tandem mass spectrometry(LC-MS/MS)has gradually been widely accepted by clinical laboratories due to its characteristics of specificity,sensitivity,and flexibility in method development.This article introduces the importance and analytical techniques for therapeutic drug monitoring,describes the application and development of liquid chromatography tandem mass spectrometry for therapeutic drug monitoring,new advances in the detection of different drug types and sample types,and challenges in automation,convenience,and standardization.

关 键 词：药物监测 液相色谱 质谱 

分 类 号：R446[医药卫生—诊断学] R969[医药卫生—临床医学]