神经生理学和神经影像学在脑卒中预后评估中的应用进展  

Progress in the application of neurophysiology and neuroimaging in the prognosis evaluation of stroke

作　　者：李脉[1] 姚黎清[1] 曾勇[1] 王文丽[1] 付雨桐 LI Mai;YAO Liqing;ZENG Yong;WANG Wenli;FU Yutong(Rehabilitation Medicine Department,the Second Affiliated Hospital of Kunming Medical University,Kunming 650000,China)

机构地区：[1]昆明医科大学第二附属医院康复医学部,云南昆明650000

出　　处：《临床医学研究与实践》2024年第30期190-194,共5页Clinical Research and Practice

基　　金：云南省院士专家工作站(No.202305AF150032);云南省科技厅科技计划项目(No.202203AC100007,No.202001AY070001-231);云南省康复临床医学中心(No.zx2019-04-02)。

摘　　要：脑卒中是一种中枢神经系统疾病,会导致大脑结构损伤和功能损伤,造成不同类型和程度的功能障碍。双峰平衡恢复模型(包括半球间竞争模型和代换模型)被认为是脑卒中后功能恢复的机制。脑卒中的恢复情况可以通过预后生物标志物来预测,这些生物标志物在细胞和分子层面与脑卒中病理生理有关,在系统神经科学层面则与脑卒中后大脑结构和功能储备有关。本文旨在回顾可预测脑卒中后功能恢复的潜在生物标志物。Stroke is a central nervous system disease,which can lead to brain structural damage and functional damage,resulting in different types and degrees of functional impairment.The bimodal balance recovery model(including the interhemispheric competition model and the substitution model)is considered to be the mechanism of functional recovery after stroke.The recovery of stroke can be predicted by prognostic biomarkers,which are related to the pathophysiology of stroke at the cellular and molecular levels,and are related to the brain structure and functional reserve after stroke at the level of systematic neuroscience.The aim of this paper is to review potential biomarkers that can predict functional recovery after stroke.

关 键 词：脑卒中 功能恢复 神经生理学 神经影像学 生物标志物 

分 类 号：R743.3[医药卫生—神经病学与精神病学]