Chiral resolution of furofuran lignans and their derivatives from the stems of Dendrobium'Sonia'  

作　　者：QIU Kaimei QIU Hao XIE Yanqiao ZHANG Siyu ZHANG Qian WANG Zhengtao HAN Zhuzhen YANG Li 

机构地区：[1]The MOE Key Laboratory of Standardization of Chinese Medicines,The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines,The Shanghai Key Laboratory for Compound Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

出　　处：《Chinese Journal of Natural Medicines》2024年第10期937-944,共8页中国天然药物（英文版）

基　　金：financially supported by the Program of Shanghai Municipal Commission of Health and Family Planning[No.ZY(2021-2023)-0215]。

摘　　要：Five new furofuran lignans and their derivatives,(-)-glaberide I 4-O-β-D-glucopyranoside(1a),(+)-glaberide I 4-O-β-D-glucopyranoside(1b),(+)-glaberide I 7'-ethoxy-4-O-β-D-glucopyranoside(2a),(-)-glaberide I 7'-ethoxy-4-O-β-D-glucopyranoside(2b),and(-)-isoeucommin A(3b),along with fifteen known analogs were isolated from the stems of Dendrobium'Sonia'.These compounds were classified into ten pairs of enantiomers or diastereoisomers via chiral resolution,and their structures were determined based on extensive spectroscopic data.Their absolute configurations were determined by hydrolysis,comparison of experimental and calculated electronic circular dichroism(ECD)data,and single-crystal X-ray diffraction analysis.The isolates were evaluated for their ability to inhibit nitric oxide(NO)production in RAW264.7 cells.Among them,syringaresinol(5)exhibited prominent inhibition activity,with an IC50 value of 28.4±3.0μmol·L~(-1),and there was a slight difference between 5a,5b and the racemic mixture 5.

关 键 词：Furofuran lignans Chiral resolution ENANTIOMERS DIASTEREOISOMERS Dendrobium'Sonia' ANTI-INFLAMMATORY 

分 类 号：R284.1[医药卫生—中药学]