Bacterial nanotechnology as a paradigm in targeted cancer therapeutic delivery and immunotherapy  

作　　者：Ahmad Gholami Milad Mohkam Saeede Soleimanian Mohammad Sadraeian Antonio Lauto 

机构地区：[1]Biotechnology Research Center,Shiraz University of Medical Sciences,Shiraz,Iran [2]Department of Pharmaceutical Biotechnology,Shiraz University of Medical Sciences,Shiraz,Iran [3]Allergy Research Center,Shiraz University of Medical Sciences,Shiraz,Iran [4]Institute for Biomedical Materials and Devices(IBMD),Faculty of Science,University of Technology Sydney,Sydney,NSW 2007,Australia [5]School of Science,University of Western Sydney,Campbelltown,NSW 2560,Australia [6]School of Medicine,University of Western Sydney,Campbelltown,NSW 2560,Australia

出　　处：《Microsystems & Nanoengineering》2024年第4期43-85,共43页微系统与纳米工程（英文）

摘　　要：Cancer,a multifaceted and diverse ailment,presents formidable obstacles to traditional treatment modalities.Nanotechnology presents novel prospects for surmounting these challenges through its capacity to facilitate meticulous and regulated administration of therapeutic agents to malignant cells while concurrently modulating the immune system to combat neoplasms.Bacteria and their derivatives have emerged as highly versatile and multifunctional platforms for cancer nanotherapy within the realm of nanomaterials.This comprehensive review delves into the multifaceted and groundbreaking implementations of bacterial nanotechnology within cancer therapy.This review encompasses four primary facets:the utilization of bacteria as living conveyors of medicinal substances,the employment of bacterial components as agents that stimulate the immune system,the deployment of bacterial vectors as tools for delivering genetic material,and the development of bacteria-derived nano-drugs as intelligent nano-medications.Furthermore,we elucidate the merits and modalities of operation pertaining to these bacterial nano-systems,along with their capacity to synergize with other cutting-edge nanotechnologies,such as CRISPR-Cas systems.Additionally,we offer insightful viewpoints regarding the forthcoming trajectories and prospects within this expanding domain.It is our deduction that bacterial nanotechnology embodies a propitious and innovative paradigm in the realm of cancer therapy,which has the potential to provide numerous advantages and synergistic effects in enhancing the outcomes and quality of life for individuals afflicted with cancer.

关 键 词：NEOPLASMS BREAKING REALM 

分 类 号：R730.51[医药卫生—肿瘤] R318.08[医药卫生—临床医学]