肾细胞癌放疗抵抗机制的研究进展  

Research advances in the mechanisms of radiotherapy resistance in renal cell carcinoma

作　　者：刘菁华 曹志飞 张永胜[1] Liu Jinghua;Cao Zhifei;Zhang Yongsheng(Department of Pathology,Second Affiliated Hospital of Soochow University,Suzhou 215004,China;Department of Clinical Medicine,Suzhou Medical College,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学附属第二医院病理科,苏州215004 [2]苏州大学苏州医学院,苏州215123

出　　处：《中华放射医学与防护杂志》2024年第10期886-890,共5页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金(12275192);秦惠莙与李政道中国大学生见习进修基金;学科建设托举工程项目(XKTJ-XK202410)。

摘　　要：放射治疗是肾细胞癌(RCC)临床治疗的有效手段。放射抗拒,即放疗过程中癌细胞对电离辐射的敏感性下降,是肿瘤放射治疗过程中的常见问题,与肿瘤转移、复发等不良结局的出现密切相关。本文以RCC放疗抵抗为切入点,从DNA损伤修复、细胞周期阻滞、抗凋亡途径的激活、自噬及肿瘤干细胞等方面阐述RCC细胞放射抗拒产生的机制,并对目前用于RCC放射治疗的增敏剂进行概述,以期为RCC放疗抵抗产生机制、放射治疗策略的改进以及药物的创新研发提供新的思路。Radiotherapy serves as an effective means in the clinical treatment of renal cell carcinoma(RCC).Radiation resistance,denoting the decreased sensitivity of cancer cells to ionizing radiation during radiotherapy,is a common problem in tumor radiotherapy that is closely associated with the occurrence of adverse outcomes like tumor metastasis and recurrence.Focusing on RCC's radiotherapy resistance,this study elucidated the radiation resistance mechanisms of RCC cells in terms of DNA damage repair,cell cycle arrest,activation of the anti-apoptotic pathway,autophagy,and cancer stem cells.Moreover,it summarized the radiosensitizers currently used in RCC radiotherapy.This study aims to provide a novel approach for the mechanism study of RCC radiotherapy resistance,the improvement of radiotherapy strategies,and the innovative research and development of drugs.

关 键 词：肾细胞癌 放疗抵抗 放射治疗 放疗增敏剂 

分 类 号：R737.11[医药卫生—肿瘤] R730.55[医药卫生—临床医学]