阿尔茨海默病认知症状和抑郁症状共有病理因素的研究进展  

Research progress on common pathological factors of cognitive and depressive symptoms in Alzheimer′s disease

作　　者：黄凌[1] 赵袁志 赵峥 吴晓红 吴向平 崔巍[2] Huang Ling;Zhao Yuanzhi;Zhao Zheng;Wu Xiaohong;Wu Xiangping;Cui Wei(Department of Psychiatry,Affiliated Kangning Hospital of Ningbo University&Affiliated Mental Health Centre,Ningbo University,Ningbo 315201,China;Health Science Center,Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学附属康宁医院精神科,宁波大学附属精神卫生中心,宁波315201 [2]宁波大学医学部,宁波315211

出　　处：《中华精神科杂志》2024年第10期692-697,共6页Chinese Journal of Psychiatry

基　　金：浙江省医药卫生科技计划(2022KY1174);宁波市自然科学基金(2021J274);宁波市自然科学基金(2021J276);宁波市医学重点学科建设项目资助(2022-F28)。

摘　　要：阿尔茨海默病患者常同时出现认知症状和抑郁症状,提示两者间有很强联系,可能具有共同病理因素。本文从遗传因素、脑神经变性、下丘脑-垂体-肾上腺轴紊乱、神经营养因子缺乏、神经炎症增强、肠道菌群失调和神经递质系统失衡等方面综述阿尔茨海默病认知症状和抑郁症状的共有病理因素,对其深入研究对今后治疗有重要意义。Patients with Alzheimer′s disease(AD)often exhibit both cognitive and depressive symptoms,suggesting a strong connection between the two,potentially indicating shared pathological factors.This article reviews the common pathological factors underlying cognitive and depressive symptoms in AD,focusing on aspects such as genetic factors,neurodegeneration,hypothalamic pituitary adrenal axis(HPA)dysfunction,neurotrophic factor deficiency,enhanced neuroinflammation,gut microbiota imbalance,and neurotransmitter systems imbalance.Further research on these common pathological factors is of great significance for future AD treatment.

关 键 词：阿尔茨海默病 抑郁 流行病学 病理因素 神经递质 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]