心率变异性在酒精依赖中的研究进展  

Research progress of heart rate variability in alcohol dependence

作　　者：金钦鋆 宋小龙 何婷玉 范妮[1] Jin Qinyun;Song Xiaolong;He Tingyu;Fan Ni(Department of Substance Dependence,Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou 510000,China)

机构地区：[1]广州医科大学附属脑科医院物质依赖科,广州510000

出　　处：《中华精神科杂志》2024年第10期698-703,共6页Chinese Journal of Psychiatry

基　　金：广州市医学重点学科项目(510101-0101200)。

摘　　要：酒精依赖(alcohol dependence,AD)是一种慢性复发性精神障碍,以酒精使用失控、强迫性饮酒和高复发率为特征。长期大量饮酒损伤酒精依赖患者心血管及神经系统,致使自主神经功能紊乱,情绪调节功能受损,这与渴求、复饮有关。对自主神经功能的监护有利于改善酒精依赖预后以及促进戒酒的维持。心率变异性(heart rate variability,HRV)可以有效反映自主神经功能。目前研究显示酒精依赖患者的自主神经功能失衡,其HRV指数与强迫性饮酒、负性情绪、注意偏倚相关,并能预测和反映酒精依赖患者出院后复饮情况,有望成为酒精依赖的有效客观的电生理指标,用以指导临床诊疗。目前酒精依赖患者HRV的研究广泛开展,本文中综述了近年来相关研究,旨在加深对该领域现状的认识,为未来的研究和临床工作提供参考。Alcohol dependence(AD)is a chronic relapsing mental disorder characterized by uncontrolled use of alcohol,compulsive drinking,and a high relapse rate.Long-term heavy drinking damages the cardiovascular and neurological systems of AD patients,resulting in dysregulation of the autonomic nervous system and impaired emotional regulation,which is also associated with craving and relapse.Monitoring autonomic nervous system is beneficial for improving the prognosis of AD and promoting abstinence.Heart rate variability(HRV)effectively reflects autonomic nervous system function.The current study found that the HRV index of AD patients with imbalanced autonomic nervous system is associated with compulsive drinking,negative mood,and attentional bias.These indices can reflect and predict post-discharge relapse in AD and are expected to become effective and objective electrophysiological indicators for guiding clinical diagnosis and treatment.Research on HRV in AD patients is currently widespread.This article reviews relevant studies in recent years,aiming to deepen understanding of the current status in this field and provide a reference for future research and clinical work.

关 键 词：酒精相关性障碍 自主神经系统 心率 

分 类 号：R749.62[医药卫生—神经病学与精神病学]