前列腺健康指数与总前列腺特异性抗原在前列腺癌诊断中的多因素及相关性分析  

Multifactor and correlation analysis of prostate health index and total prostate-specific antigen in the diagnosis of prostate cancer

作　　者：刘帅康 蒋凯峰 谭昌文 孙钟海 朴敏虎[1] LIU Shuaikang;JIANG Kaifeng;TAN Changwen;SUN Zhonghai;PIAO Minhu(Department of Urology Affiliated Hospital of Yanbian University,Yanji 133000,China)

机构地区：[1]延边大学附属医院泌尿外科,吉林延吉133000

出　　处：《延边大学医学学报》2024年第3期300-302,共3页Journal of Medical Science Yanbian University

摘　　要：目的:比较前列腺健康指数(PHI)与总前列腺特异性抗原(tPSA)在前列腺癌(Pca)诊断中受临床各因素影响的程度,探讨这些因素与上述指标之间的相关性,旨在为临床医师判断疑似Pca患者是否穿刺活检提供依据。方法:收集自2021年3月至12月于延边大学附属医院接受治疗的82例因tPSA异常而行穿刺活检患者的术前检查资料及其病理检查结果。根据病理结果将数据分为良性组和恶性组,分析前列腺体积(PV)、炎症、膀胱结石、留置导尿管等因素对tPSA以及PHI值的影响,并进一步分析比较了tPSA以及PHI在诊断Pca方面的灵敏度以及特异度。结果:良性组与恶性组tPSA、PHI、PV相比差异均有统计学意义(P<0.05);留置导尿管、泌尿系感染差异无统计学意义(P>0.05)。有无导尿管与tPSA的Spearman相关性为正相关关系(P<0.05);与PHI无相关性(P>0.05)。PV、病理评分与tPSA、PHI的Spearman相关性为正相关关系(P<0.05)。结论:有无导尿管以及PV均影响血清tPSA和PHI值水平,其中PV是影响两者的独立因素,相比之下,PHI受导尿管的干扰较tPSA小。OBJECTIVE To compare the impact of prostate health index(PHI)and total prostate-specific antigen(tPSA)on various clinical factors in the diagnosis of prostate cancer(PCa),and investigate the correlation between these factors and the above indicators,so as to provide evidence for clinicians in judging whether to do aspiration biopsy for suspected Pca patients.METHODS The preoperative examination data and pathological findings of 82 patients who underwent aspiration biopsy due to abnormal tPSA in the Affiliated Hospital of Yanbian University from March to December 2021 were collected.The data were divided into benign and malignant groups according to pathological results.The effects of prostate volume(PV),inflammation,bladder calculi,indwelling catheter and other factors on tPSA and PHI values were analyzed,and the sensitivity and specificity of tPSA and PHI in diagnosing Pca were further analyzed and compared.RESULTS There were significant differences in tPSA,PHI and PV between benign and malignant group(P<0.05).There was no statistical significance between indwelling catheter and urinary tract infection(P>0.05).There was a positive Spearman correlation between the presence and absence of catheter and tPSA(P<0.05),and no correlation with PHI(P>0.05).PV and pathological scores were positively correlated with Spearman correlation of tPSA and PHI(P<0.05).CONCLUSION The presence or absence of catheter and PV affect serum tPSA and PHI levels,in which PV is an independent factor affecting both,while the interference of PHI by catheter is less than that of tPSA.

关 键 词：前列腺健康指数 总前列腺特异性抗原 前列腺癌 相关性 

分 类 号：R737[医药卫生—肿瘤]