Detecting biomarkers by dynamic nuclear polarization enhanced magnetic resonance  

作　　者：Shizhen Chen Lei Zhang Sha Li Yaping Yuan Bin Jiang Zhongxing Jiang Xu Zhang Xin Zhou Maili Liu 

机构地区：[1]State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,National Center for Magnetic Resonance in Wuhan,Wuhan Institute of Physics and Mathematics,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences,Wuhan 430071,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]School of Biomedical Engineering,Hainan University,Haikou 570228,China

出　　处：《National Science Review》2024年第9期65-81,共17页国家科学评论（英文版）

基　　金：funded by the National Natural Science Foundation of China(22327901,21921004,82127802,and U21A20392);the National Key R&D Program of China(2018YFA0704000).

摘　　要：Hyperpolarization stands out as a technique capable of significantly enhancing the sensitivity of nuclear magnetic resonance(NMR)and magnetic resonance imaging(MRI).Dynamic nuclear polarization(DNP),among various hyperpolarization methods,has gained prominence for its efficacy in real-time monitoring of metabolism and physiology.By administering a hyperpolarized substrate through dissolution DNP(dDNP),the biodistribution and metabolic changes of the DNP agent can be visualized spatiotemporally.This approach proves to be a distinctive and invaluable tool for non-invasively studying cellular metabolism in vivo,particularly in animal models.Biomarkers play a pivotal role in influencing the growth and metastasis of tumor cells by closely interacting with them,and accordingly detecting pathological alterations of these biomarkers is crucial for disease diagnosis and therapy.In recent years,a range of hyperpolarized DNP molecular bioresponsive agents utilizing various nuclei,such as^(13)C,^(15)N,^(31)P,^(89)Y,etc.,have been developed.In this context,we explore how these magnetic resonance signals of nuclear spins enhanced by DNP respond to biomarkers,including pH,metal ions,enzymes,or redox processes.This review aims to offer insights into the design principles of responsive DNP agents,target selection,and the mechanisms of action for imaging.Such discussions aim to propel the future development and application of DNP-based biomedical imaging agents.

关 键 词：MRI dynamic nuclear hyperpolarization BIOMARKER responsive agent 

分 类 号：R445.2[医药卫生—影像医学与核医学]