动物实验证据整合方法研究的进展与挑战  

Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence

作　　者：郑卿勇 李腾飞 许建国 周泳佳 马智超 王娜 李莫兰 杨雯景 吴佩润 王海东[6] 田金徽[1,2] ZHENG Qingyong;LI Tengfei;XU Jianguo;ZHOU Yongjia;MA Zhichao;WANG Na;LI Molan;YANG Wenjing;WU Peirun;WANG Haidong;TIAN Jinhui(Evidence-Based Medicine Center,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China;Key Laboratory of Evidence-based Medicine of Gansu Province,Lanzhou 730000,China;School of Nursing,Gansu University of Chinese Medicine,Lanzhou 730000,China;The Second Clinical Medical College of Lanzhou University,Lanzhou 730000,China;The First Clinical School of Medicine,Lanzhou University,Lanzhou 730000,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]兰州大学循证医学中心,兰州大学基础医学院,兰州730000 [2]甘肃省循证医学重点实验室,兰州730000 [3]甘肃中医药大学护理学院,兰州730000 [4]兰州大学第二临床医学院,兰州730000 [5]兰州大学第一临床医学院,兰州730000 [6]甘肃省中医院,兰州730050

出　　处：《实验动物与比较医学》2024年第5期567-576,共10页Laboratory Animal and Comparative Medicine

基　　金：2023年中央财政转移支付地方项目“中医药循证能力建设”(2101704)。

摘　　要：动物实验证据整合是生物医学研究中的关键环节,为疾病机制的深入研究与新药开发等提供了重要的先验信息。目前,动物模型在模拟人类疾病方面发挥着不可替代的作用,但动物实验证据整合在实践中仍面临诸多挑战,包括受重视程度不足、研究设计的异质性明显、高发表偏倚、与临床研究实践存在差距等。本文首先指出动物实验原始研究证据的现存问题,包括动物模型的选择和适用性、动物实验研究设计的考量、动物实验证据转化的影响因素等方面;然后介绍了多种动物实验证据整合方法的应用进展,如系统评价与Meta分析、系统评价再评价/伞形综述、范围综述、证据图谱等;最后探讨了目前动物实验证据整合面临的主要挑战以及针对性的改进策略,旨在提高动物实验研究成果向临床实践转化的效率,并推动循证医学的发展。未来,通过不断优化原始实验研究方案与证据整合实践,有望逐步构建一个更为科学、高效的动物实验证据综合环境,为临床试验与人类健康事业作出更大的贡献。Integrating evidence from animal experiments is a critical component of biomedical research,providing essential prior information for in-depth investigations of disease mechanisms and new drug development.Animal models have played an irreplaceable role in simulating human diseases.However,the integration of evidence from animal experiments has faced numerous challenges,including insufficient emphasis,significant heterogeneity in study designs,high publication bias,and discrepancies with clinical research practices.This paper first identifies existing issues in the original research evidence from animal experiments,such as the selection and applicability of animal models,considerations in the design of experimental studies,and factors influencing the translation of animal experimental evidence.It then discusses various methods for integrating this evidence,including systematic review and meta-analysis,overview of systematic review/umbrella review,scoping review,and evidence mapping,while highlighting recent advancements in their application.Finally,the paper addresses the main challenges currently encountered in the integration of evidence from animal experiments and proposes targeted improvement strategies aimed at enhancing the efficiency of translating research outcomes into clinical practice and promoting the advancement of evidence-based medicine.By continuously optimizing original experimental research protocols and evidence integration practices,this work aims to establish a more efficient and scientific environment for the synthesis of evidence from animal experiments,ultimately contributing to clinical trials and human health.

关 键 词：动物实验 证据整合 研究进展 循证医学 

分 类 号：Q95-33[生物学—动物学] R-332[医药卫生]