Applications and advancements in animal models for antiviral research on mosquito-borne arboviruses  

作　　者：Megan Caifeng Tang Ka Heng Wong Adzzie Shazleen Azman Rafidah Lani 

机构地区：[1]School of Science,Monash University Malaysia,Sunway,Selangor,Malaysia [2]Department of Medical Microbiology,Faculty of Medicine,Universiti Malaya,Kuala Lumpur,Malaysia

出　　处：《Animal Models and Experimental Medicine》2024年第5期673-684,共12页动物模型与实验医学（英文）

摘　　要：Vector-borne diseases caused by arthropod-borne viruses(arboviruses) are a considerable challenge to public health globally. Mosquito-borne arboviruses, such as Chikungunya, Dengue, and Zika viruses, cause a range of human illnesses and may be fatal. Currently, efforts to control these diseases still face challenges due to growing vector resistance towards insecticides, urbanization, and limited effective antiviral treatments and vaccines. Animal models are crucial in antiviral research on mosquito-borne arboviruses, playing a role in understanding disease mechanisms,vaccine development, and toxicity testing, but the application of animal models still faces the challenges of ethical considerations and animal-to-human translational success. Genetically engineered mouse models, hamster models and non-human primate(NHP) are currently used in arbovirus research, but new models such as tree shrews and novel humanized mice are emerging. In the context of Malaysian research, the use of long-tailed macaques as potential NHP models for arbovirus research is possible;however, it faces the ethical dilemma of using an endangered species for scientific purposes. Overall, animal models play a crucial role in advancing infectious disease research, but a balance between medical research and species conservation must be upheld.

关 键 词：animal models ARBOVIRUS biomedical research ETHICS i nfectious diseases 

分 类 号：R-332[医药卫生] R511