N-乙酰转移酶10在肿瘤发生发展中作用的研究进展  

Progress on the role of N-acetyltransferase 10 in tumor development

作　　者：古仲嘉 赖思莹 陈敦金[1] 杜丽丽[1] GU Zhongjia;LAI Siying;CHEN Dunjin;DU Lili(Guangzhou Institute of Obstetrics and Gynecology,Guangdong Provincial Key Laboratory of Major Obstetric Diseases,Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology,Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine,the Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510000,China)

机构地区：[1]广州医科大学附属第三医院、广州妇产科研究所、广东省产科重大疾病重点实验室、广东省妇产疾病临床医学研究中心、粤港澳母胎医学高校联合实验室,广东广州510000

出　　处：《基础医学与临床》2024年第11期1589-1593,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(82371674)。

摘　　要：N-乙酰转移酶10(NAT10)是一种广泛表达于多种组织和细胞中的蛋白质,NAT10的高表达与肿瘤的侵袭、转移、耐药性密切相关。NAT10促进肿瘤发生发展的机制涉及因NAT10表达或定位的改变对细胞周期、mRNA稳定性、翻译效率以及相关通路的调控等,从而影响肿瘤的发生发展及预后。N-acetyltransferase10(NAT10)is a protein widely expressed in a variety of tissues and cells.The high expression of NAT10 is closely related to tumor invasion,metastasis and drug resistance.The mechanism of NAT10 promoting tumor genesis and development involves the regulation of cell cycle,mRNA stability,translation efficiency and related pathways due to the changes in the expression or location of NAT10,thus affecting the occurrence,development and prognosis of tumors.

关 键 词：N-乙酰转移酶10 N4-乙酰胞苷修饰 肿瘤 

分 类 号：R731-31[医药卫生—肿瘤]